Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | PHGDH | O43175 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | CASP7 | P55210 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.46 |
| ▸ | IDO1 | P14902 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11492017 | 0.87 | TSHR (0.62) | MAPK1ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL2676946 | 0.85 | MAPK1 (0.64) | MAPK1ALDH1A1LMNAHTTL3MBTL1 | |
| SCHEMBL11479021 | 0.85 | MAPT (0.59) | MAPK1ALDH1A1TSHRL3MBTL1MAPT | |
| SCHEMBL2329868 | 0.85 | L3MBTL1 (0.51) | MAPK1ALDH1A1LMNATSHRL3MBTL1 | |
| SCHEMBL5384243 | 0.84 | L3MBTL1 (0.61) | MAPK1ALDH1A1LMNAHTTTSHR | |
| SCHEMBL3253899 | 0.83 | L3MBTL1 (0.77) | MAPK1ALDH1A1TSHRL3MBTL1MAPT | |
| SCHEMBL31495088 | 0.81 | VCAM1 (0.56) | MAPK1ALDH1A1LMNAHTTTSHR | |
| SCHEMBL16489005 | 0.81 | AKR1C3 (0.67) | ALDH1A1L3MBTL1MAPTPHGDHAPP | |
| SCHEMBL1624563 | 0.79 | CXCL8 (0.46) | MAPK1ALDH1A1TSHRL3MBTL1MAPT | |
| SCHEMBL4588213 | 0.79 | L3MBTL1 (0.55) | MAPK1ALDH1A1LMNAL3MBTL1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5661169-A | HAVE AFFINITY FOR VASOPRESSIN AND/OR OXYTOCIN RECEPTORS | SANOFI (FR) | 1997-08-26 | — | — | US | disclosed |
| US-5585394-A | INHIBITOR, ANTAGONIST OF VASOPRESSIN OR OXYTOCIN | SANOFI (FR) | 1996-12-17 | — | — | US | disclosed |
| EP-0694536-A1 | 1-Benzyl-1,3-dihydro-2H-benzimidazol-2-one derivatives, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1996-01-31 | — | — | EP | disclosed |
| EP-0636614-A1 | Derivatives of 1-benzenesulfonyl-1,3-dihydro-2H-benzimidazol-2-one, their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-02-01 | — | — | EP | disclosed |