Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4510192 | 0.84 | ALDH1A1 (0.38) | KMT2AKDM4EALDH1A1HPGDPTPN1 | |
| SCHEMBL9001643 | 0.82 | KMT2A (0.53) | HSD11B1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL11256211 | 0.81 | PPARG (0.42) | KMT2AKDM4ENR1H2NR1H3NPC1 | |
| SCHEMBL11257623 | 0.78 | HDAC3 (0.45) | KMT2AKDM4EALDH1A1NPC1CASP3 | |
| SCHEMBL28867944 | 0.77 | KMT2A (0.46) | HSD11B1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL8812454 | 0.77 | KMT2A (0.49) | HSD11B1KMT2AKDM4EALDH1A1HPGD | |
| SCHEMBL28272164 | 0.77 | TSPO (0.37) | KMT2AALDH1A1HPGDLMNATP53 | |
| SCHEMBL9049204 | 0.75 | POLQ (0.39) | KDM4EALDH1A1TP53SMN1; SMN2CES1 | |
| SCHEMBL3807892 | 0.75 | ALDH1A1 (0.51) | KMT2AKDM4EALDH1A1 | |
| SCHEMBL8614764 | 0.75 | ALDH1A1 (0.44) | HSD11B1KMT2AKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5596020-A | Amino bi- and tri-carbocyclic alkane bis-aryl squalene synthase inhibitors | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5561143-A | ANTICHOLESTEROL AGENTS, ANTILIPEMIC AGENTS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-10-01 | — | — | US | disclosed |
| US-5534532-A | ANTICHOLESTEROL AGENTS, SQUALENE SYNTHASE INHIBITOR | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5494918-A | ANTICHOLESTEROL AGENTS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1996-02-27 | — | — | US | disclosed |
| US-5455260-A | Anticholesterol agents; reduction of serum cholesterol without reducing mevalonic metabolite synthesis; side effect | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-10-03 | — | — | US | disclosed |
| US-5395846-A | Amino Bi- and tri-carbocyclic aklane bis-aryl squalene synthase inhibitors | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-03-07 | — | — | US | disclosed |
| US-5385912-A | Hypocholesterolemic or hypolipidemic agents | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-01-31 | — | — | US | disclosed |
| WO-1995000146-A1 | AMINO BI- AND TRI-CARBOCYCLIC ALKANE BIS-ARYL SQUALENE SYNTHASE INHIBITORS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1995-01-05 | — | — | WO | disclosed |
| WO-1994027601-A1 | ALIPHATIC AMINO BIS-ARYL SQUALENE SYNTHASE INHIBITORS | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1994-12-08 | — | — | WO | disclosed |
| WO-1992015579-A1 | MULTICYCLIC TERTIARY AMINE POLYAROMATIC SQUALENE SYNTHETASE INHIBITORS | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1992-09-17 | — | — | WO | disclosed |