SCHEMBL11256211

SCHEMBL11256211

CN(C(=O)c1ccccc1)c1ccccc1CCC(=O)O

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 1/20 0.42
KEAP1 Q14145 1/20 0.42
PTGER1 P34995 1/20 0.41
PTGER4 P35408 1/20 0.41
PTGER3 P43115 1/20 0.41
PTGER2 P43116 1/20 0.41
KMT2A Q03164 2/20 0.41
NR4A2 P43354 1/20 0.41
KDM4E B2RXH2 1/20 0.41
NPSR1 Q6W5P4 2/20 0.40
FFAR1 O14842 1/20 0.40
ELANE P08246 1/20 0.39
NR1H2 P55055 1/20 0.38
NR1H3 Q13133 1/20 0.38
NPC1 O15118 1/20 0.38
LMNA P02545 1/20 0.38
TP53 P04637 1/20 0.38
CASP3 P42574 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11257623 0.91 HDAC3 (0.45) KMT2ANR4A2KDM4EFFAR1NPC1
SCHEMBL11264455 0.90 ALDH1A1 (0.42) KDM4ENPSR1FFAR1LMNASMN1; SMN2
SCHEMBL11260689 0.84 GPBAR1 (0.47) KDM4EFFAR1
SCHEMBL11255842 0.82 ALDH1A1 (0.40) SMN1; SMN2EGFRERBB2
SCHEMBL5698045 0.82 KEAP1 (0.48) KEAP1PTGER1PTGER4PTGER3PTGER2
SCHEMBL11259485 0.81 LTB4R (0.44) SMN1; SMN2
SCHEMBL8885290 0.81 HSD11B1 (0.44) KMT2AKDM4ENR1H2NR1H3NPC1
SCHEMBL7375380 0.80 ITGB3 (0.43) KMT2ASMN1; SMN2ITGB3ITGA2B
SCHEMBL9001643 0.79 KMT2A (0.53) KMT2AKDM4ENR1H2NR1H3NPC1
SCHEMBL19665869 0.78 NPSR1 (0.43) KEAP1PTGER1PTGER4PTGER3PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4322439-A ω-[2-(N-Lower alkyl-benzamido)-phenyl]-alkanoic acids, their use, and medicaments containing them BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1982-03-30 US claimed
EP-0003532-B1 OMEGA-(2-(N-LOWER ALKYL-BENZAMIDO)-PHENYL)-ALKANOIC ACIDS, THEIR USE AND PREPARATION, AND MEDICAMENTS CONTAINING THEM Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1982-04-28 EP disclosed
US-4325955-A DIURETICS AMERICAN CYANAMID COMPANY (US) 1982-04-20 US disclosed
US-4322439-A ω-[2-(N-Lower alkyl-benzamido)-phenyl]-alkanoic acids, their use, and medicaments containing them BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1982-03-30 US disclosed
WO-1979000586-A1 W-(2-N-LOWER ALKYL-BENZAMIDO)-PHENYL)-ALKANOIC ACIDS,THEIR USE AND PREPARATION,AND MEDICAMENTS CONTAINING THEM BYK GULDEN LOMBERG CHEM FAB (DE) 1979-08-23 WO disclosed
EP-0003532-A1 Omega-(2-(N-lower alkyl-benzamido)-phenyl)-alkanoic acids, their use and preparation, and medicaments containing them Byk Gulden Lomberg Chemische Fabrik GmbH (DE) 1979-08-22 EP disclosed