Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.37 |
| ▸ | HSP90B1 | P14625 | 1/20 | 0.37 |
| ▸ | TRAP1 | Q12931 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8884976 | 0.88 | HSD11B1 (0.39) | MAPK1ALDH1A1HPGDCYP3A4TDP1 | |
| SCHEMBL8885532 | 0.85 | MAPK1 (0.44) | MAPK1ALDH1A1HPGDHSP90AA1HSP90B1 | |
| SCHEMBL8885575 | 0.79 | ALDH1A1 (0.40) | ALDH1A1COXFA4HIF1AEPAS1HSD11B1 | |
| SCHEMBL8885558 | 0.77 | MAPK1 (0.43) | MAPK1ALDH1A1HPGDHSP90AA1HSP90B1 | |
| SCHEMBL9397057 | 0.77 | MAPK1 (0.42) | MAPK1ALDH1A1HPGDHSP90AA1HSP90B1 | |
| SCHEMBL8884017 | 0.75 | HIF1A (0.41) | ALDH1A1HIF1AEPAS1HSD11B1KMT2A | |
| SCHEMBL8884015 | 0.74 | HSD11B1 (0.39) | ALDH1A1HPGDKDM4EHIF1AEPAS1 | |
| SCHEMBL9050508 | 0.74 | HIF1A (0.43) | ALDH1A1COXFA4HIF1AEPAS1HSD11B1 | |
| SCHEMBL9053708 | 0.74 | HSD11B1 (0.39) | MAPK1ALDH1A1TSHRGAAKDM4E | |
| SCHEMBL8947156 | 0.74 | MAPK1 (0.60) | MAPK1ALDH1A1HPGDHSP90AA1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5677324-A | MUSCLE RELAXANTS | PFIZER INC. (US) | 1997-10-14 | — | — | US | disclosed |
| EP-0690855-B1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LTD (GB) | 1996-12-18 | — | — | EP | disclosed |
| WO-1994020491-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |