Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 6/20 | 0.41 |
| ▸ | EPAS1 | Q99814 | 6/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886146 | 0.94 | HIF1A (0.40) | HIF1AEPAS1HSD11B1ALDH1A1POLB | |
| SCHEMBL8885347 | 0.93 | HIF1A (0.39) | HIF1AEPAS1HSD11B1ALDH1A1POLB | |
| SCHEMBL9050197 | 0.91 | HIF1A (0.39) | HIF1AEPAS1HSD11B1 | |
| SCHEMBL9050508 | 0.88 | HIF1A (0.43) | HIF1AEPAS1HSD11B1ALDH1A1HTT | |
| SCHEMBL8886385 | 0.87 | HIF1A (0.42) | HIF1AEPAS1HSD11B1ALDH1A1MEN1 | |
| SCHEMBL9051319 | 0.87 | ALDH1A1 (0.47) | HIF1AEPAS1HSD11B1ALDH1A1POLB | |
| SCHEMBL8886788 | 0.84 | HSD11B1 (0.40) | HSD11B1ALDH1A1POLBHTTMEN1 | |
| SCHEMBL8885575 | 0.83 | ALDH1A1 (0.40) | HIF1AEPAS1HSD11B1ALDH1A1POLB | |
| SCHEMBL8884015 | 0.82 | HSD11B1 (0.39) | HIF1AEPAS1HSD11B1ALDH1A1POLB | |
| SCHEMBL9049776 | 0.77 | HRH3 (0.36) | HSD11B1ALDH1A1POLBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5677324-A | MUSCLE RELAXANTS | PFIZER INC. (US) | 1997-10-14 | — | — | US | disclosed |
| EP-0690855-B1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LTD (GB) | 1996-12-18 | — | — | EP | disclosed |
| WO-1994020491-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |