Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 12/20 | 0.43 |
| ▸ | EPAS1 | Q99814 | 11/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | COXFA4 | O00483 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8886385 | 0.90 | HIF1A (0.42) | HIF1AEPAS1CA12CA9HSD11B1 | |
| SCHEMBL8884017 | 0.88 | HIF1A (0.41) | HIF1AEPAS1CA12CA9HSD11B1 | |
| SCHEMBL9050197 | 0.87 | HIF1A (0.39) | HIF1AEPAS1HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL8885575 | 0.83 | ALDH1A1 (0.40) | HIF1AEPAS1CA12CA9HSD11B1 | |
| SCHEMBL8886146 | 0.82 | HIF1A (0.40) | HIF1AEPAS1HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL8885347 | 0.81 | HIF1A (0.39) | HIF1AEPAS1HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL9051319 | 0.78 | ALDH1A1 (0.47) | HIF1AEPAS1HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL9050314 | 0.77 | SLC6A2 (0.42) | CA12CA9HSD11B1SLC6A2SLC6A4 | |
| SCHEMBL8884976 | 0.75 | HSD11B1 (0.39) | HIF1AEPAS1HSD11B1ALDH1A1COXFA4 | |
| SCHEMBL8884015 | 0.74 | HSD11B1 (0.39) | HIF1AEPAS1CA12CA9HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381422-B1 | Tetrahydrobenzimidazole derivatives | YAMANOUCHI PHARMA CO LTD (JP) | 1996-10-23 | — | — | EP | claimed |
| EP-0690855-B1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LTD (GB) | 1996-12-18 | — | — | EP | disclosed |
| WO-1994020491-A1 | BENZOPYRANES AS POTASSIUM CHANNEL OPENERS | PFIZER LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |