Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.45 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.43 |
| ▸ | F7 | P08709 | 2/20 | 0.43 |
| ▸ | F3 | P13726 | 2/20 | 0.43 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20132718 | 0.88 | KEAP1 (0.51) | MAPTMAPK1TDP1L3MBTL1CCR5 | |
| SCHEMBL682767 | 0.87 | MAPT (0.49) | MAPTMAPK1TDP1L3MBTL1C5AR1 | |
| SCHEMBL27737866 | 0.86 | MAPT (0.42) | MAPTMAPK1TDP1L3MBTL1CCR5 | |
| SCHEMBL28815272 | 0.85 | CCR5 (0.49) | MAPTMAPK1TDP1L3MBTL1C5AR1 | |
| SCHEMBL8886562 | 0.84 | HPGD (0.49) | MAPTMAPK1TDP1L3MBTL1C5AR1 | |
| SCHEMBL30280437 | 0.84 | HPGD (0.49) | MAPTMAPK1TDP1L3MBTL1C5AR1 | |
| SCHEMBL10710291 | 0.84 | CFD (0.49) | MAPTMAPK1TDP1L3MBTL1C5AR1 | |
| SCHEMBL17833745 | 0.79 | SMPD1 (0.53) | MAPK1RAB9AALDH1A1F2F10 | |
| SCHEMBL11833134 | 0.79 | F2 (0.47) | MAPTMAPK1TDP1L3MBTL1C5AR1 | |
| SCHEMBL12738664 | 0.79 | NPC1 (0.55) | MAPTRAB9AALDH1A1F2F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5674909-A | FOR TREATMENT OF CARDIOVASCULAR DISORDERS | ZAMBON GROUP (IT) | 1997-10-07 | — | — | US | disclosed |