Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | APEX1 | P27695 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11305741 | 0.85 | NPC1 (0.50) | MAPTALDH1A1RAB9ANPC1POLB | |
| SCHEMBL21654186 | 0.80 | MAPT (0.44) | MAPTALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL24107099 | 0.78 | NR1H4 (0.44) | MAPTALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL8886735 | 0.78 | ACHE (0.41) | MAPTALDH1A1LMNATDP1TSHR | |
| SCHEMBL10591101 | 0.77 | NR1H4 (0.43) | MAPTALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL8886871 | 0.76 | LDHA (0.42) | MAPTALDH1A1MAPK1RAB9ANPC1 | |
| SCHEMBL8890078 | 0.76 | ALDH1A1 (0.40) | MAPTALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL8995789 | 0.76 | PPARA (0.40) | TSHRL3MBTL1POLB | |
| SCHEMBL28306045 | 0.76 | LTA4H (0.44) | MAPTLMNATDP1ALOX15 | |
| SCHEMBL25331886 | 0.75 | SLC6A4 (0.39) | MAPTALDH1A1LMNATSHRKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691340-A | CENTRAL NERVOUS SYSTEM DISORDERS, STROKES, CARDIOVASCULAR DISORDERS, ALZHEIMER*S DISEASE OR ANTIINFLAMMATORY AGENTS | ADIR ET COMPAGNIE (FR) | 1997-11-25 | — | — | US | disclosed |