Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.32 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.32 |
| ▸ | PARP1 | P09874 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
| ▸ | NAMPT | P43490 | 1/20 | 0.30 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8887585 | 0.87 | GPR139 (0.40) | KMT2AGPR139ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL9067904 | 0.85 | KMT2A (0.48) | KMT2AGPR139ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL1055212 | 0.76 | GPR139 (0.52) | KMT2AGPR139ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL14417102 | 0.76 | GPR139 (0.52) | KMT2AGPR139ALDH1A1MAPTL3MBTL1 | |
| Succinimide SCHEMBL8888235 | 0.74 | KMT2A (0.44) | KMT2AGPR139ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8595095 | 0.73 | GPR139 (0.55) | KMT2AGPR139ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL9724362 | 0.72 | PARP1 (0.36) | KMT2AALDH1A1MAPTHTTPARP1 | |
| SCHEMBL8904453 | 0.71 | SLC1A2 (0.40) | KMT2AALDH1A1MAPTITGB1ITGA5 | |
| SCHEMBL8597576 | 0.68 | ALDH1A1 (0.42) | KMT2AGPR139ALDH1A1MAPTL3MBTL1 | |
| SCHEMBL8140165 | 0.68 | ITGB1 (0.34) | ITGB1ITGA5EGLN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681927-A | COMPLEXES | NEORX CORPORATION (US) | 1997-10-28 | — | — | US | disclosed |
| US-5616692-A | Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy | NEORX CORPORATION (US) | 1997-04-01 | — | — | US | disclosed |
| EP-0284071-B1 | Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy | NEORX CORP (US) | 1994-06-08 | — | — | EP | disclosed |
| US-5091514-A | Antitumor, anticarcinogenic agents | NEORX CORPORATION (US) | 1992-02-25 | — | — | US | disclosed |
| US-4965392-A | DIAGNOSIS, RADIOTHERAPY OF TUMORS | NEORX CORPORATION (US) | 1990-10-23 | — | — | US | disclosed |
| EP-0284071-A2 | Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy | NEORX CORPORATION (US) | 1988-09-28 | — | — | EP | disclosed |