SCHEMBL8889484

SCHEMBL8889484

O=c1ccc(-c2c(-c3cc(Cl)cc(Cl)c3)n[nH]c2-c2ccccc2)n[nH]1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.53
HPGD P15428 3/20 0.48
MAPK13 O15264 1/20 0.43
RAF1 P04049 1/20 0.43
MAPK12 P53778 1/20 0.43
MAPK11 Q15759 1/20 0.43
MAPK14 Q16539 1/20 0.43
GPR119 Q8TDV5 1/20 0.43
KDM4E B2RXH2 3/20 0.39
ALDH1A1 P00352 3/20 0.39
GAA P10253 2/20 0.39
CYP2C9 P11712 2/20 0.39
CYP2C19 P33261 2/20 0.39
CYP3A4 P08684 1/20 0.39
HTT P42858 1/20 0.39
HSD17B10 Q99714 2/20 0.38
NPC1 O15118 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MAPK1 P28482 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8888361 0.92 CYP1A2 (0.50) CYP1A2HPGDMAPK13RAF1MAPK12
SCHEMBL8888295 0.90 CYP1A2 (0.53) CYP1A2HPGDMAPK13RAF1MAPK12
SCHEMBL8889786 0.87 CYP1A2 (0.45) CYP1A2HPGDMAPK11MAPK14GPR119
SCHEMBL8889476 0.83 CYP1A2 (0.51) CYP1A2HPGDGPR119KDM4EALDH1A1
SCHEMBL8890194 0.82 CYP1A2 (0.50) CYP1A2HPGDMAPK13RAF1MAPK12
SCHEMBL8887885 0.82 CYP1A2 (0.50) CYP1A2HPGDMAPK13RAF1MAPK12
SCHEMBL8887621 0.82 CYP1A2 (0.50) CYP1A2HPGDMAPK14GPR119KDM4E
SCHEMBL8888926 0.82 KMT2A (0.57) CYP1A2HPGDGPR119KDM4EALDH1A1
SCHEMBL7584622 0.80 CYP1A2 (0.58) CYP1A2HPGDGPR119CYP2C9CYP2C19
SCHEMBL8889663 0.79 CYP1A2 (0.47) CYP1A2HPGDGPR119KDM4EALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997001551-A1 PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-01-16 WO disclosed