SCHEMBL8890194

SCHEMBL8890194

O=c1ccc(-c2c(-c3cccc(O)c3)n[nH]c2-c2ccccc2)n[nH]1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.50
MAPK13 O15264 1/20 0.43
RAF1 P04049 1/20 0.43
BRAF P15056 1/20 0.43
MAPK12 P53778 1/20 0.43
MAPK11 Q15759 1/20 0.43
MAPK14 Q16539 1/20 0.43
BRDT Q58F21 1/20 0.43
PTPN1 P18031 1/20 0.43
GPR119 Q8TDV5 1/20 0.41
RPS6KA3 P51812 1/20 0.40
HPGD P15428 2/20 0.40
ALK Q9UM73 1/20 0.40
PIK3CG P48736 1/20 0.39
MLLT3 P42568 1/20 0.38
MLLT1 Q03111 1/20 0.38
KDM4E B2RXH2 2/20 0.37
ALDH1A1 P00352 2/20 0.37
GAA P10253 2/20 0.37
DYRK1A Q13627 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8887621 0.85 CYP1A2 (0.50) CYP1A2MAPK14GPR119HPGDKDM4E
SCHEMBL8887885 0.85 CYP1A2 (0.50) CYP1A2MAPK13RAF1MAPK12MAPK11
SCHEMBL8888361 0.85 CYP1A2 (0.50) CYP1A2MAPK13RAF1MAPK12MAPK11
SCHEMBL8889484 0.82 CYP1A2 (0.53) CYP1A2MAPK13RAF1MAPK12MAPK11
SCHEMBL8889663 0.82 CYP1A2 (0.47) CYP1A2GPR119HPGDKDM4EALDH1A1
SCHEMBL8886941 0.82 NR1H2 (0.49) CYP1A2MAPK13RAF1MAPK12MAPK11
SCHEMBL8897726 0.80 JAK2 (0.46) CYP1A2MAPK13RAF1MAPK12MAPK11
SCHEMBL8888926 0.80 KMT2A (0.57) CYP1A2GPR119HPGDKDM4EALDH1A1
SCHEMBL8888295 0.80 CYP1A2 (0.53) CYP1A2MAPK13RAF1MAPK12MAPK11
SCHEMBL8889786 0.80 CYP1A2 (0.45) CYP1A2MAPK11MAPK14GPR119HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997001551-A1 PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-01-16 WO disclosed