SCHEMBL8889663

SCHEMBL8889663

CCc1cccc(-c2n[nH]c(-c3ccccc3)c2-c2ccc(=O)[nH]n2)c1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 2/20 0.47
NOTUM Q6P988 1/20 0.43
FGFR1 P11362 1/20 0.41
IDO1 P14902 1/20 0.40
GPR119 Q8TDV5 1/20 0.39
MAPT P10636 1/20 0.38
HPGD P15428 2/20 0.37
CCNE2 O96020 2/20 0.36
CDK4 P11802 2/20 0.36
CCND1 P24385 2/20 0.36
CCNE1 P24864 2/20 0.36
CDK2 P24941 2/20 0.36
MEN1 O00255 1/20 0.36
LMNA P02545 1/20 0.36
KMT2A Q03164 1/20 0.36
BCL2 P10415 1/20 0.36
KDM4E B2RXH2 2/20 0.36
ALDH1A1 P00352 2/20 0.36
TP53 P04637 1/20 0.36
HSD17B10 Q99714 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8887621 0.84 CYP1A2 (0.50) CYP1A2NOTUMGPR119MAPTHPGD
SCHEMBL8888641 0.83 MAPT (0.46) CYP1A2FGFR1MAPTHPGDMEN1
SCHEMBL8887885 0.82 CYP1A2 (0.50) CYP1A2NOTUMIDO1GPR119MAPT
SCHEMBL8888361 0.82 CYP1A2 (0.50) CYP1A2NOTUMIDO1GPR119MAPT
SCHEMBL8890194 0.82 CYP1A2 (0.50) CYP1A2GPR119HPGDCCNE2CDK4
SCHEMBL8886941 0.81 NR1H2 (0.49) CYP1A2NOTUMMAPTHPGDCCNE2
SCHEMBL8889202 0.81 CYP1A2 (0.41) CYP1A2GPR119MAPTMEN1KMT2A
SCHEMBL8889484 0.79 CYP1A2 (0.53) CYP1A2IDO1GPR119HPGDMEN1
SCHEMBL8888926 0.79 KMT2A (0.57) CYP1A2GPR119MAPTHPGDCCNE2
SCHEMBL8888264 0.79 CYP1A2 (0.44) CYP1A2GPR119MAPTHPGDCCNE2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997001551-A1 PYRAZOLE COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-01-16 WO disclosed