Known targets — ChEMBL curated mechanism
AGTR1DHFRGABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGARTNR3C2PBP2XPTGS1PTGS2VKORC1blablaT-3blaT-4blaT-5blaT-6dacAdacBdacCfolAftsImrcAmrcBmrdApbp1apbp1bpbp2apbp2bpbp3polthyA
The experimentally established mechanism targets of Potassium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.54 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | AHR | P35869 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.47 |
| ▸ | MPO | P05164 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.47 |
| ▸ | HTR1D | P28221 | 1/20 | 0.47 |
| ▸ | HTR1B | P28222 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | HTR7 | P34969 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567690 | 0.95 | MEN1 (0.58) | MEN1KMT2ACYP3A4GPR84MAPT | |
| SCHEMBL155191 | 0.95 | MEN1 (0.58) | MEN1KMT2ACYP3A4GPR84MAPT | |
| SCHEMBL28624457 | 0.93 | MEN1 (0.56) | MEN1KMT2ACYP3A4GPR84MAPT | |
| SCHEMBL10550137 | 0.93 | MEN1 (0.56) | MEN1KMT2ACYP3A4GPR84MAPT | |
| Water SCHEMBL27616945 | 0.93 | MEN1 (0.56) | MEN1KMT2ACYP3A4GPR84MAPT | |
| Methane SCHEMBL5065725 | 0.93 | MEN1 (0.56) | MEN1KMT2ACYP3A4GPR84MAPT | |
| SCHEMBL27702719 | 0.93 | MEN1 (0.56) | MEN1KMT2ACYP3A4GPR84MAPT | |
| SCHEMBL4855690 | 0.93 | MEN1 (0.56) | MEN1KMT2ACYP3A4GPR84MAPT | |
| Hydrochloric Acid SCHEMBL28628671 | 0.93 | MEN1 (0.56) | MEN1KMT2ACYP3A4GPR84MAPT | |
| SCHEMBL27714884 | 0.91 | MEN1 (0.54) | MEN1KMT2ACYP3A4GPR84MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686625-A | AMINATION, HYDROGENATION OF GLYOXYLIC ACID OR ESTER HEMIACETAL | DSM CHEMIE LINZ GMBH (AT) | 1997-11-11 | — | — | US | disclosed |