Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NOS1 | P29475 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.50 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.48 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8893900 | 0.81 | SMN1; SMN2 (0.60) | ALDH1A1SMN1; SMN2NOS1KMT2AMEN1 | |
| SCHEMBL12709067 | 0.75 | TBXAS1 (0.50) | ALDH1A1NOS1KMT2AMEN1POLB | |
| SCHEMBL11640934 | 0.74 | CYP19A1 (0.56) | NOS1KMT2AMEN1POLBCYP19A1 | |
| SCHEMBL11492895 | 0.73 | CYP17A1 (0.53) | KMT2AMEN1POLBCYP19A1CYP11B1 | |
| SCHEMBL11495476 | 0.73 | POLB (0.49) | NOS1KMT2AMEN1POLBCYP19A1 | |
| SCHEMBL8893008 | 0.71 | CYP19A1 (0.62) | CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL13761576 | 0.71 | MEN1 (0.86) | ALDH1A1NOS1KMT2AMEN1POLB | |
| SCHEMBL8684902 | 0.71 | QPCT (0.73) | NOS1KMT2AMEN1POLBKDM4E | |
| SCHEMBL9200864 | 0.70 | CYP19A1 (0.58) | NOS1KMT2AMEN1POLBCYP19A1 | |
| SCHEMBL11079276 | 0.70 | CYP19A1 (0.49) | KMT2AMEN1POLBCYP19A1CYP11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997027175-A1 | SUBSTITUTED ETHYL α,α - DIARYLMETHYL ETHER DERIVATIVES | GUILFORD PHARMACEUTICALS INC. (US) | 1997-07-31 | — | — | WO | disclosed |