Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 4/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | THRA | P10827 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 3/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18932875 | 0.85 | THRB (0.55) | THRBRORCTHRAMAPT | |
| SCHEMBL23863342 | 0.81 | THRA (0.53) | THRBTHRAMAPT | |
| SCHEMBL18918559 | 0.81 | THRB (0.48) | THRBRORCTHRA | |
| SCHEMBL282509 | 0.81 | ATM (0.46) | HTR2ASLC6A4KCNH2THRBRORC | |
| SCHEMBL18932877 | 0.80 | THRB (0.46) | HTR2ASLC6A4KCNH2THRBRORC | |
| SCHEMBL23863340 | 0.80 | THRB (0.45) | HTR2ASLC6A4KCNH2THRBRORC | |
| SCHEMBL4960799 | 0.80 | THRB (0.46) | HTR2ASLC6A4KCNH2THRBRORC | |
| SCHEMBL8892903 | 0.79 | RORC (0.60) | THRBRORCTHRA | |
| SCHEMBL3221253 | 0.79 | POLB (0.48) | THRBTHRAPOLBMAPTALDH1A1 | |
| SCHEMBL282344 | 0.78 | THRB (0.59) | HTR2ASLC6A4KCNH2THRBRORC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5654468-A | ANTILIPID, ANTICHOLESTEROL AGENTS | CIBA-GEIGY CORPORATION (US) | 1997-08-05 | — | — | US | disclosed |
| US-5569674-A | ANTICHOLESTEROL AGENTS | CIBA-GEIGY CORPORATION (US) | 1996-10-29 | — | — | US | disclosed |
| US-5401772-A | Anticholesterol agents with aromatic amines | CIBA-GEIGY CORPORATION (US) | 1995-03-28 | — | — | US | disclosed |