Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.68 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.68 |
| ▸ | MTNR1A | P48039 | 7/20 | 0.60 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.60 |
| ▸ | NOTUM | Q6P988 | 4/20 | 0.59 |
| ▸ | LTA4H | P09960 | 3/20 | 0.58 |
| ▸ | PLA2G2A | P14555 | 3/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SPR | P35270 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | BLM | P54132 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | IDO1 | P14902 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HTR7 | P34969 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27693665 | 0.89 | CYP2C19 (0.53) | HPGDCYP2C19MTNR1AMTNR1BNOTUM | |
| SCHEMBL6763965 | 0.88 | MTNR1A (0.74) | HPGDCYP2C19MTNR1AMTNR1BNOTUM | |
| SCHEMBL5350957 | 0.86 | KMT2A (0.73) | HPGDCYP2C19POLBMEN1RAB9A | |
| SCHEMBL1960963 | 0.84 | SPR (0.78) | HPGDNOTUMKDM4EALDH1A1MAPT | |
| SCHEMBL11351947 | 0.84 | HTR7 (0.69) | HPGDMTNR1AMTNR1BNOTUMLTA4H | |
| SCHEMBL10550760 | 0.84 | LTA4H (0.59) | HPGDMTNR1AMTNR1BNOTUMLTA4H | |
| SCHEMBL11080741 | 0.83 | MTNR1A (0.78) | HPGDMTNR1AMTNR1BNOTUMLTA4H | |
| SCHEMBL20242784 | 0.83 | NOTUM (0.78) | MTNR1AMTNR1BNOTUMLTA4HPLA2G2A | |
| SCHEMBL12720741 | 0.82 | SPR (0.75) | HPGDCYP2C19MTNR1AMTNR1BNOTUM | |
| SCHEMBL11353910 | 0.82 | HTR1A (0.79) | CYP2C19MTNR1AMTNR1BNOTUMLTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594034-A | ADMINISTERING DIRECT ACTING 5-HYDROXYTRYPTAMINE AGONIST TO MAMMAL | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5594025-A | Method of inhibiting gastric acid secretion with 5-substituted-3-aminochromane | ELI LILLY AND COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| EP-0455510-B1 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | LILLY CO ELI (US) | 1996-11-27 | — | — | EP | disclosed |
| US-5576352-A | Method of inhibiting gastric acid secretion with aryloxypropanolamines | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |
| US-5457120-A | Antisecretory and antiserotonine agents | ELI LILLY AND COMPANY (US) | 1995-10-10 | — | — | US | disclosed |
| US-5340838-A | Administering serotonin agonist to mammals | ELI LILLY AND COMPANY (US) | 1994-08-23 | — | — | US | disclosed |
| US-5258379-A | ADMINISTERING IN AN EFFECTIVE DOSAGE TO MAMMALS | ELI LILLY AND COMPANY (US) | 1993-11-02 | — | — | US | disclosed |
| US-5158956-A | Administering serotonin receptor agonist | ELI LILLY AND COMPANY (US) | 1992-10-27 | — | — | US | disclosed |
| US-5096908-A | 5-HT1A agonist | ELI LILLY AND COMPANY (US) | 1992-03-17 | — | — | US | disclosed |
| EP-0455510-A2 | Use of 5-HT1A receptor agonist compounds for inhibiting gastric acid secretion | ELI LILLY AND COMPANY (US) | 1991-11-06 | — | — | EP | disclosed |