Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31637815 | 0.84 | HTR7 (0.55) | HTR7SMN1; SMN2MAPK8POLBCHRNB2 | |
| SCHEMBL23291726 | 0.84 | HTR7 (0.55) | HTR7SMN1; SMN2MAPK8POLBCHRNB2 | |
| SCHEMBL28524909 | 0.83 | HTR7 (0.47) | HTR7SMN1; SMN2TSHRMAPK8POLB | |
| SCHEMBL31637967 | 0.83 | HTR7 (0.54) | HTR7SMN1; SMN2TSHRMAPK8CHRNB2 | |
| SCHEMBL3804347 | 0.81 | KMT2A (0.50) | HTR7SMN1; SMN2POLBKDM4EALDH1A1 | |
| SCHEMBL11848310 | 0.81 | L3MBTL1 (0.49) | SMN1; SMN2MAPK8POLBCXCR1CXCR2 | |
| SCHEMBL28904516 | 0.81 | SMN1; SMN2 (0.45) | SMN1; SMN2MAPK8POLBCXCR1CXCR2 | |
| SCHEMBL31638063 | 0.80 | HTR7 (0.43) | HTR7SMN1; SMN2TSHRMAPK8CHRNB2 | |
| SCHEMBL29160233 | 0.79 | OGG1 (0.50) | HTR7SMN1; SMN2TSHRMAPK8KDM4E | |
| SCHEMBL7783634 | 0.79 | HTR7 (0.43) | HTR7SMN1; SMN2MAPK8KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4271674-A1 | CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2023-11-08 | — | — | EP | disclosed |
| WO-2022225914-A1 | CARBOXY-BENZIMIDAZOLE GLP-1R MODULATING COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2022-10-27 | — | — | WO | disclosed |
| US-5614634-A | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-03-25 | — | — | US | disclosed |
| US-5440044-A | Leukotriene-B4 derivatives, process for their production and their use as pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1995-08-08 | — | — | US | disclosed |