Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CXCR1 | P25024 | 2/20 | 0.40 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | XIAP | P98170 | 1/20 | 0.39 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8892987 | 0.81 | HTR7 (0.50) | SMN1; SMN2MAPK8POLBCXCR1CXCR2 | |
| SCHEMBL11848310 | 0.81 | L3MBTL1 (0.49) | SMN1; SMN2MAPK8POLBCXCR1CXCR2 | |
| SCHEMBL7583697 | 0.75 | TSHR (0.56) | SMN1; SMN2POLBCXCR1CXCR2KDM4E | |
| SCHEMBL4707883 | 0.75 | XIAP (0.45) | MAPK8KDM4EMAPTXIAPBIRC2 | |
| SCHEMBL28004747 | 0.74 | NOS3 (0.42) | — | |
| SCHEMBL23582438 | 0.74 | MAPT (0.53) | SMN1; SMN2MAPTALDH1A1LMNA | |
| SCHEMBL8984346 | 0.74 | CNR1 (0.49) | SMN1; SMN2POLBKDM4EMAPTALDH1A1 | |
| SCHEMBL23582337 | 0.74 | CYP4F2 (0.44) | ALDH1A1LMNA | |
| SCHEMBL3924027 | 0.73 | ALDH1A1 (0.41) | SMN1; SMN2POLBKDM4EMAPTXIAP | |
| SCHEMBL22556890 | 0.73 | ACHE (0.41) | SMN1; SMN2MAPK8KDM4EMAPTXIAP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112047957-B | Substituted pyrimidinediones and their use | 广东东阳光药业有限公司 | 2022-02-01 | — | — | CN | disclosed |
| CN-112047957-A | Substituted pyrimidinediones and their use | 广东东阳光药业有限公司 | 2020-12-08 | — | — | CN | disclosed |