Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 2/20 | 0.57 |
| ▸ | NPC1L1 | Q9UHC9 | 12/20 | 0.50 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | DDR1 | Q08345 | 2/20 | 0.37 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.37 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894056 | 0.84 | BDKRB2 (0.59) | BDKRB2NPC1L1EPHX1 | |
| SCHEMBL8892471 | 0.78 | BDKRB2 (0.55) | BDKRB2NPC1L1DDR1 | |
| SCHEMBL1855447 | 0.76 | NPC1L1 (0.70) | BDKRB2NPC1L1DDR1 | |
| SCHEMBL8897218 | 0.74 | NPC1L1 (0.60) | BDKRB2NPC1L1DDR1 | |
| SCHEMBL8894157 | 0.73 | NPC1L1 (0.59) | BDKRB2NPC1L1DDR1 | |
| SCHEMBL17149529 | 0.73 | EPHX1 (0.43) | NPC1L1EPHX1HPGDDDB1CRBN | |
| SCHEMBL23288815 | 0.71 | KCNH2 (0.44) | NPC1L1EPHX1HPGDDDB1CRBN | |
| SCHEMBL5134060 | 0.71 | GRIN2B (0.49) | BDKRB2NPC1L1DDR1 | |
| SCHEMBL14282652 | 0.69 | GRIN2B (0.50) | NPC1L1DDB1CRBN | |
| SCHEMBL31537333 | 0.69 | CTSD (0.44) | EPHX1HPGDDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610142-A | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids | SCIOS INC. (US) | 1997-03-11 | — | — | US | disclosed |