Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BDKRB2 | P30411 | 2/20 | 0.59 |
| ▸ | NPC1L1 | Q9UHC9 | 12/20 | 0.49 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8894874 | 0.84 | BDKRB2 (0.57) | BDKRB2NPC1L1EPHX1 | |
| SCHEMBL8892471 | 0.83 | BDKRB2 (0.55) | BDKRB2NPC1L1 | |
| SCHEMBL8893259 | 0.77 | SLC6A9 (0.50) | BDKRB2BACE1CTSDEPHX1 | |
| SCHEMBL8893501 | 0.75 | BDKRB2 (0.53) | BDKRB2NPC1L1 | |
| SCHEMBL1855447 | 0.74 | NPC1L1 (0.70) | BDKRB2NPC1L1 | |
| SCHEMBL8894157 | 0.73 | NPC1L1 (0.59) | BDKRB2NPC1L1 | |
| SCHEMBL8897218 | 0.73 | NPC1L1 (0.60) | BDKRB2NPC1L1 | |
| SCHEMBL7957340 | 0.71 | KDM4E (0.46) | BACE1EPHX1 | |
| SCHEMBL5134060 | 0.69 | GRIN2B (0.49) | BDKRB2NPC1L1 | |
| SCHEMBL18940727 | 0.69 | ENPP2 (0.42) | BACE1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5610142-A | Bradykinin antagonist pseudopeptide derivatives of substituted 4-keto-1,3,8-triazaspiro[4.5]decan-3-alkanoic acids | SCIOS INC. (US) | 1997-03-11 | — | — | US | disclosed |