Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GHSR | Q92847 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | LTB4R | Q15722 | 12/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL88995 | 0.93 | TSHR (0.45) | KDM4EALDH1A1ABCB11LMNACYP1A2 | |
| SCHEMBL8264291 | 0.88 | LTB4R (0.49) | KDM4EALDH1A1ABCB11LMNACYP1A2 | |
| SCHEMBL13490840 | 0.87 | LTB4R (0.44) | KDM4EALDH1A1ABCB11LMNACYP1A2 | |
| SCHEMBL1911257 | 0.87 | NCF1 (0.43) | KDM4EALDH1A1ABCB11LMNACYP1A2 | |
| SCHEMBL89106 | 0.86 | HTR3E (0.48) | KDM4EALDH1A1ABCB11LMNACYP1A2 | |
| SCHEMBL8265068 | 0.85 | LTB4R (0.41) | KDM4EALDH1A1ABCB11LMNACYP1A2 | |
| SCHEMBL13490841 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1ABCB11LMNACYP1A2 | |
| SCHEMBL19422787 | 0.81 | NPC1 (0.49) | KDM4EALDH1A1LMNAGAAHPGD | |
| SCHEMBL11942312 | 0.79 | KDM4E (0.47) | KDM4EALDH1A1GAAHPGDSMN1; SMN2 | |
| SCHEMBL15087665 | 0.79 | TSHR (0.44) | KDM4EALDH1A1ABCB11LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129411-B2 | Organic compounds | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100029647-A1 | 3,4,(5)-SUBSTITUTED TETRAHYDROPHYRIDINES | NOVARTIS AG (CH) | 2010-02-04 | — | — | US | disclosed |
| US-20090192148-A1 | Organic Compounds | NOVARTIS AG (CH) | 2009-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100029647-A1 | 3,4,(5)-SUBSTITUTED TETRAHYDROPHYRIDINES | REN, PAH, ACE | KDM4E 1290/4885ALDH1A1 412/4885ABCB11 340/4885 |
| US-20090192148-A1 | Organic Compounds | REN, ACE, AGTR1 | KDM4E 1650/4885ALDH1A1 38/4885ABCB11 469/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.