Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.44 |
| ▸ | KIF11 | P52732 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | ELANE | P08246 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | VDR | P11473 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9548452 | 0.81 | KIF11 (0.47) | CYP2C19KIF11HIF1AALDH1A1ELANE | |
| SCHEMBL40498 | 0.80 | KIF11 (0.50) | CYP2C19KIF11HIF1AALDH1A1HTT | |
| SCHEMBL17965751 | 0.79 | KIF11 (0.48) | CYP2C19KIF11HIF1AALDH1A1ELANE | |
| SCHEMBL2822033 | 0.78 | KCNN4 (0.48) | CYP2C19KIF11HIF1AALDH1A1SMN1; SMN2 | |
| SCHEMBL10412017 | 0.78 | HSD11B1 (0.44) | HSD11B1CYP2C19KIF11HIF1AELANE | |
| SCHEMBL7054160 | 0.77 | KIF11 (0.47) | CYP2C19KIF11HIF1AALDH1A1ELANE | |
| SCHEMBL28446874 | 0.77 | KIF11 (0.52) | CYP2C19KIF11HIF1AALDH1A1HTT | |
| SCHEMBL7055637 | 0.77 | KIF11 (0.47) | CYP2C19KIF11HIF1AALDH1A1ELANE | |
| SCHEMBL17237864 | 0.77 | KIF11 (0.47) | HSD11B1CYP2C19KIF11HIF1AALDH1A1 | |
| SCHEMBL7057598 | 0.77 | KIF11 (0.47) | CYP2C19KIF11HIF1AALDH1A1ELANE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120010281-A1 | ANTIMICROBIAL AND ANTITUBERCULAR COMPOUNDS | THE TRUSTEES OF PRINCETON UNIVERSITY (US) | 2012-01-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120010281-A1 | ANTIMICROBIAL AND ANTITUBERCULAR COMPOUNDS | TBK1, TBCD, TBKBP1 | HSD11B1 2820/4885CYP2C19 3918/4885KIF11 4022/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.