SCHEMBL889553

SCHEMBL889553

CC[C@H]1O[C@@H](n2cnc3c(N(Cc4ccccc4[N+](=O)[O-])C(=O)OC(C)(C)C)ncnc32)CC1O[Si](C)(C)C(C)(C)C

nearest known ligand 0.38

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SLC29A1 Q99808 7/20 0.37
NPEPPS P55786 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12570159 0.93 SLC29A1 (0.36) SLC29A1NPEPPS
SCHEMBL889555 0.92 SLC29A1 (0.34) SLC29A1
SCHEMBL889701 0.91 SLC29A1 (0.34) SLC29A1NPEPPS
SCHEMBL9913213 0.88 NPEPPS (0.35) SLC29A1NPEPPS
SCHEMBL12762670 0.86 SLC29A1 (0.35) SLC29A1
SCHEMBL12570168 0.85 SLC29A1 (0.33) SLC29A1
SCHEMBL12762666 0.85 SLC29A1 (0.33) SLC29A1NPEPPS
SCHEMBL889632 0.85 P2RX3 (0.33) SLC29A1
SCHEMBL14789012 0.85 P2RX3 (0.33) SLC29A1
SCHEMBL9913204 0.84 SLC29A1 (0.35) SLC29A1NPEPPS

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8969535-B2 Photocleavable labeled nucleotides and nucleosides and methods for their use in DNA sequencing LASERGEN, INC. (US) 2015-03-03 US disclosed
US-20130072388-A1 PHOTOCLEAVABLE LABELED NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN IN DNA SEQUENCING AGILENT TECHNOLOGIES, INC. 2013-03-21 US disclosed
US-8361727-B2 3′OH-unblocked, nucleotides and nucleosides base modified with labels and photocleavable, terminating groups and methods for their use in DNA sequencing LASERGEN, INC. (US) 2013-01-29 US disclosed
US-20110287427-A1 3'OH-UNBLOCKED, NUCLEOTIDES AND NUCLEOSIDES BASE MODIFIED WITH LABELS AND PHOTOCLEAVABLE, TERMINATING GROUPS AND METHODS FOR THEIR USE IN DNA SEQUENCING LASERGEN, INC. (US) 2011-11-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130072388-A1 PHOTOCLEAVABLE LABELED NUCLEOTIDES AND NUCLEOSIDES AND METHODS FOR THEIR USE IN IN DNA SEQUENCING UNG, NT5C3B, OGG1 SLC29A1 189/4885NPEPPS 390/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.