SCHEMBL8897477

SCHEMBL8897477

COC(C)Oc1ccc(C=CC(O)=Cc2ccccc2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TRPA1 O75762 1/20 0.45
GSK3B P49841 2/20 0.43
BACE1 P56817 2/20 0.43
TRPM8 Q7Z2W7 2/20 0.43
LTB4R Q15722 1/20 0.42
LTB4R2 Q9NPC1 1/20 0.42
KMT2A Q03164 2/20 0.42
CYP3A4 P08684 2/20 0.42
MEN1 O00255 1/20 0.42
ALDH1A1 P00352 1/20 0.42
MAPT P10636 1/20 0.42
HSPD1 P10809 1/20 0.42
TNFRSF1A P19438 1/20 0.42
MAOB P27338 1/20 0.42
HSPE1 P61604 1/20 0.42
CYP1B1 Q16678 1/20 0.42
BCHE P06276 1/20 0.42
NFKB1 P19838 1/20 0.42
NFKB2 Q00653 1/20 0.42
RELA Q04206 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8898528 0.86 LTB4R (0.44) LTB4RLTB4R2KMT2ACYP3A4MAPT
SCHEMBL6276080 0.83 ABCG2 (0.42) TRPA1TRPM8LTB4RLTB4R2KMT2A
SCHEMBL546104 0.77 MAPT (0.56) TRPM8KMT2ACYP3A4MEN1ALDH1A1
SCHEMBL6866016 0.76 CA12 (0.41) GSK3BBACE1LTB4RLTB4R2KMT2A
SCHEMBL9998805 0.76 KMT2A (0.47) TRPA1GSK3BBACE1TRPM8KMT2A
SCHEMBL8897481 0.75 TRPA1 (0.44) TRPA1TRPM8LTB4RLTB4R2KMT2A
SCHEMBL28130605 0.75 MMP1 (0.73) KMT2ACYP3A4MEN1ALDH1A1MAPT
SCHEMBL15347287 0.75 KMT2A (0.56) GSK3BBACE1TRPM8KMT2ACYP3A4
SCHEMBL7193949 0.74 GAA (0.36) TRPM8LTB4RLTB4R2KMT2AMEN1
SCHEMBL15048548 0.74 FOS (0.58) TRPM8KMT2ACYP3A4ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5670299-A COATING A PHOTORESISTS POLYMER ON A SUBSTRATE, DEVELOPMENT AND HEAT TREATMENT WAKO PURE CHEMICAL INDUSTRIES, LTD. (JP) 1997-09-23 US disclosed