Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | LTA4H | P09960 | 5/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | SOD1 | P00441 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | DAO | P14920 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.39 |
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL98311 | 0.94 | ALDH1A1 (0.47) | MAOBALDH1A1MEN1RAB9AKMT2A | |
| SCHEMBL2170360 | 0.82 | CA12 (0.42) | MAOAMAOBPTGS2ALDH1A1MEN1 | |
| SCHEMBL11307105 | 0.80 | MAOB (0.47) | MAOAMAOBLTA4HPTGS2ALDH1A1 | |
| SCHEMBL11510990 | 0.77 | MAOA (0.52) | MAOAMAOBLTA4HPTGS2ALDH1A1 | |
| SCHEMBL457634 | 0.75 | MAOA (0.74) | MAOAMAOBLTA4HPTGS2ALDH1A1 | |
| SCHEMBL9242729 | 0.75 | MAOA (0.74) | MAOAMAOBLTA4HPTGS2ALDH1A1 | |
| SCHEMBL25245394 | 0.74 | MAOB (0.54) | MAOAMAOBLTA4HPTGS2RAB9A | |
| SCHEMBL5536815 | 0.73 | ALDH3A1 (0.47) | MAOBLTA4HPTGS2MEN1RAB9A | |
| Formaldehyde SCHEMBL28347928 | 0.73 | MAOA (0.64) | MAOAMAOBLTA4HALDH1A1MEN1 | |
| SCHEMBL514661 | 0.72 | APP (0.42) | MAOBALDH1A1RAB9AKMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5352666-A | Using a renin inhibitor | SCHERING CORPORATION (US) | 1994-10-04 | — | — | US | claimed |
| US-3985875-A | RENIN INHIBITION, ANTIHYPERTENSIVE, ANTICHOLESTEROL AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JA) | 1976-10-12 | — | — | US | claimed |
| US-5688770-A | RENIN INHIBITOR AND BETA ADRENERGIC BLOCKING AGENT | SCHERING CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| US-5352666-A | Using a renin inhibitor | SCHERING CORPORATION (US) | 1994-10-04 | — | — | US | disclosed |
| WO-1992013564-A1 | COMBINATION OF AN ANGIOTENSIN II ANTAGONIST OR RENIN INHIBITOR WITH A NEUTRAL ENDOPEPTIDASE INHIBITOR | SCHERING CORPORATION (US) | 1992-08-20 | — | — | WO | disclosed |
| EP-0498361-A2 | Combination of an angiotensin II antagonist or renin inhibitor with a neutral endopeptidase inhibitor | SCHERING CORPORATION (US) | 1992-08-12 | — | — | EP | disclosed |
| EP-0246381-B1 | RENIN INHIBITORS AND METHODS FOR USING SAME | SCHERING CORPORATION (US) | 1990-08-01 | — | — | EP | disclosed |
| US-4906613-A | Antiglaucoma compositions and methods | SCHERING CORPORATION (US) | 1990-03-06 | — | — | US | disclosed |
| EP-0246381-A1 | Renin inhibitors and methods for using same | SCHERING CORPORATION (US) | 1987-11-25 | — | — | EP | disclosed |
| US-3985875-A | RENIN INHIBITION, ANTIHYPERTENSIVE, ANTICHOLESTEROL AGENTS | DAINIPPON PHARMACEUTICAL CO., LTD. (JA) | 1976-10-12 | — | — | US | disclosed |