Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMPD1 | P17405 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.52 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.50 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.50 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8663810 | 0.93 | LMNA (0.59) | SMPD1LMNAHPGDMEN1KMT2A | |
| SCHEMBL183994 | 0.91 | LMNA (0.70) | SMPD1LMNAHPGDMEN1KMT2A | |
| SCHEMBL731203 | 0.90 | LMNA (0.62) | SMPD1LMNAHPGDMEN1KMT2A | |
| SCHEMBL391547 | 0.88 | MEN1 (0.71) | SMPD1LMNAHPGDMEN1KMT2A | |
| SCHEMBL27395439 | 0.87 | RAB9A (0.68) | LMNAMEN1KMT2ASMN1; SMN2RAB9A | |
| SCHEMBL3129603 | 0.87 | MEN1 (0.74) | SMPD1LMNAHPGDMEN1KMT2A | |
| SCHEMBL8900859 | 0.85 | MEN1 (0.76) | SMPD1MEN1KMT2ASMN1; SMN2FFAR1 | |
| SCHEMBL14345811 | 0.84 | LMNA (0.62) | SMPD1LMNAHPGDMEN1KMT2A | |
| SCHEMBL3592344 | 0.84 | SMN1; SMN2 (0.62) | SMPD1LMNAHPGDMEN1KMT2A | |
| SCHEMBL29475634 | 0.84 | LMNA (0.69) | SMPD1LMNAHPGDMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0663391-B1 | Sulphuric acid esters of sugar alcohols for the treatment of arteriosclerotic changes in the vascular walls | HOFFMANN LA ROCHE (CH) | 1997-04-09 | — | — | EP | disclosed |
| US-5521160-A | COMPOUNDS FOR TREATMENT OF ATHERIOSCLEROSIS IN BLOOD VESSELS AND PREVENTION OF RESTENOSIS AFTER ANGIOPLASTY | HOFFMANN-LA ROCHE INC. (US) | 1996-05-28 | — | — | US | disclosed |
| EP-0663391-A1 | Sulphuric acid esters of sugar alcohols for the treatment of arteriosclerotic changes in the vascular walls | F. HOFFMANN-LA ROCHE AG (CH) | 1995-07-19 | — | — | EP | disclosed |