Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 5/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | CASP3 | P42574 | 1/20 | 0.45 |
| ▸ | CASP7 | P55210 | 1/20 | 0.45 |
| ▸ | CASP9 | P55211 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901056 | 0.88 | PTPN1 (0.50) | PTPN1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL2226744 | 0.82 | PTPN1 (0.52) | PTPN1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL12093638 | 0.81 | ALDH1A1 (0.56) | PTPN1ALDH1A1MEN1KMT2AMAPT | |
| Acetic Acid SCHEMBL27488564 | 0.81 | MTNR1A (0.50) | MAPTNPSR1HPGDLMNACYP3A4 | |
| SCHEMBL3643251 | 0.81 | PTPN1 (0.49) | PTPN1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL23228992 | 0.80 | MTNR1A (0.49) | ALDH1A1MEN1KMT2AMAPTHPGD | |
| SCHEMBL17327987 | 0.80 | ALDH1A1 (0.54) | PTPN1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL177349 | 0.80 | ALDH1A1 (0.58) | PTPN1ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4773036 | 0.79 | ALDH1A1 (0.58) | PTPN1ALDH1A1MEN1KMT2ANPSR1 | |
| SCHEMBL4770864 | 0.79 | ALDH1A1 (0.53) | PTPN1ALDH1A1MAPTNPSR1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686481-A | INDOLE DERIVATIVES; TREATING HYPERTENSION, RENAL FAILURE, CEREBROVASCULAR DISEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1997-11-11 | — | — | US | disclosed |
| EP-0676959-A4 | ENDOTHELIN RECEPTOR ANTAGONISTS. | SMITHKLINE BEECHAM CORP (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0676959-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1995-10-18 | — | — | EP | disclosed |
| WO-1994014434-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1994-07-07 | — | — | WO | disclosed |