Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 2/20 | 0.42 |
| ▸ | SLC25A5 | P05141 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.31 |
| ▸ | PRKACA | P17612 | 1/20 | 0.31 |
| ▸ | CDC25B | P30305 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | EDNRB | P24530 | 1/20 | 0.30 |
| ▸ | EDNRA | P25101 | 1/20 | 0.30 |
| ▸ | S100A4 | P26447 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | IDO1 | P14902 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8900155 | 0.83 | AKT1 (0.47) | AKT1SLC25A5SMN1; SMN2AKR1B1APAF1 | |
| SCHEMBL8902037 | 0.81 | AKT1 (0.44) | AKT1SLC25A5SMN1; SMN2APAF1TDP2 | |
| SCHEMBL8528779 | 0.77 | AKT1 (0.42) | AKT1SLC25A5SMN1; SMN2APAF1KMT2A | |
| SCHEMBL8907639 | 0.74 | CTH (0.38) | AKT1SLC25A5SMN1; SMN2CDC25BLMNA | |
| SCHEMBL31237790 | 0.73 | AKT1 (0.49) | AKT1SMN1; SMN2APAF1TDP2PRKACA | |
| SCHEMBL9755756 | 0.71 | SMN1; SMN2 (0.40) | AKT1SMN1; SMN2AKR1B1KMT2AMEN1 | |
| SCHEMBL8531983 | 0.70 | AKT1 (0.46) | AKT1SMN1; SMN2APAF1TDP2CDC25B | |
| SCHEMBL8900149 | 0.68 | AKT1 (0.34) | AKT1PRKACA | |
| SCHEMBL8901501 | 0.68 | HSP90AA1 (0.46) | AKT1SMN1; SMN2TDP2CDC25BKMT2A | |
| SCHEMBL8900997 | 0.68 | HSP90AA1 (0.46) | AKT1SMN1; SMN2TDP2CDC25BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5606037-A | Processes antineoplastic heteronaphthoquinones | BIOCHEM PHARMA INC. (CA) | 1997-02-25 | — | — | US | claimed |
| US-5606037-A | Processes antineoplastic heteronaphthoquinones | BIOCHEM PHARMA INC. (CA) | 1997-02-25 | — | — | US | disclosed |