Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.67 |
| ▸ | THRB | P10828 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | XDH | P47989 | 4/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.41 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 5/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.39 |
| ▸ | NR4A1 | P22736 | 2/20 | 0.39 |
| ▸ | APEX1 | P27695 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901182 | 1.00 | HTT (0.67) | HTTTHRBLMNAXDHAKR1C3 | |
| SCHEMBL8901190 | 1.00 | HTT (0.67) | HTTTHRBLMNAXDHAKR1C3 | |
| SCHEMBL8248041 | 0.80 | HTT (1.00) | HTTTHRBGAAMAPTMEN1 | |
| SCHEMBL8898611 | 0.80 | HTT (1.00) | HTTTHRBGAAMAPTMEN1 | |
| SCHEMBL8898736 | 0.80 | HTT (0.98) | HTTTHRBGAAMAPTMEN1 | |
| SCHEMBL8711631 | 0.77 | LMNA (0.43) | HTTTHRBLMNAXDHAKR1C3 | |
| SCHEMBL7965236 | 0.68 | ALDH1A1 (0.57) | LMNAXDHAKR1C3AKR1C2AKR1C1 | |
| SCHEMBL8900555 | 0.67 | THRB (0.77) | HTTTHRBMAPTMEN1KMT2A | |
| SCHEMBL8898696 | 0.67 | THRB (0.77) | HTTTHRBMAPTMEN1KMT2A | |
| SCHEMBL8898703 | 0.67 | THRB (0.77) | HTTTHRBMAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812840-A1 | NOVEL QUINUCLIDINE DERIVATIVES HAVING TRICYCLIC FUSED HETERO RING | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-12-17 | — | — | EP | disclosed |