Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | HPGD | P15428 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | NPY1R | P25929 | 1/20 | 0.45 |
| ▸ | NPY2R | P49146 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12933393 | 0.82 | KDM4E (0.55) | KDM4EALDH1A1HPGDMAPTMEN1 | |
| SCHEMBL8902085 | 0.82 | CISD1 (0.50) | TDP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL5754001 | 0.82 | TDP1 (0.47) | TDP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL2337780 | 0.79 | HTT (0.51) | TDP1KDM4EALDH1A1HPGDPOLB | |
| SCHEMBL11569742 | 0.78 | CISD1 (0.53) | TDP1KDM4EALDH1A1MAPTLMNA | |
| SCHEMBL6844761 | 0.78 | POLB (0.58) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL12316423 | 0.78 | TDP1 (0.45) | TDP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL8902454 | 0.78 | HTR4 (0.46) | TDP1KDM4EPOLBHTTMEN1 | |
| SCHEMBL22987101 | 0.77 | HPGD (0.50) | TDP1KDM4EALDH1A1HPGDMAPT | |
| SCHEMBL133355 | 0.77 | AGER (0.58) | TDP1KDM4EALDH1A1HPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5686482-A | DOPAMINE RECEPTOR ANTAGONIST | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1997-11-11 | — | — | US | disclosed |
| EP-0757985-A1 | N-(3-PYRROLIDINYL)BENZAMIDE DERIVATIVE | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1997-02-12 | — | — | EP | disclosed |