Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Methacrylic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | DGKA | P23743 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.31 |
| ▸ | LPAR6 | P43657 | 1/20 | 0.31 |
| ▸ | LPAR1 | Q92633 | 1/20 | 0.31 |
| ▸ | LPAR4 | Q99677 | 1/20 | 0.31 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.31 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.31 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Phosphoric Acid SCHEMBL16620209 | 0.95 | TSHR (0.53) | TSHRKDM4EDUSP3MEN1KMT2A | |
| Phosphoric Acid SCHEMBL4988141 | 0.95 | TSHR (0.53) | TSHRKDM4EDUSP3MEN1KMT2A | |
| Methacrylic Acid SCHEMBL8075678 | 0.94 | TSHR (0.46) | TSHRKDM4EDUSP3MEN1KMT2A | |
| Methacrylic Acid SCHEMBL25415594 | 0.93 | TSHR (0.55) | TSHRKDM4EDUSP3MEN1KMT2A | |
| Methacrylic Acid SCHEMBL33306 | 0.93 | TSHR (0.55) | TSHRKDM4EDUSP3MEN1KMT2A | |
| Methacrylic Acid SCHEMBL5435140 | 0.93 | TSHR (0.55) | TSHRKDM4EDUSP3MEN1KMT2A | |
| Methacrylic Acid SCHEMBL283894 | 0.93 | TSHR (0.55) | TSHRKDM4EDUSP3MEN1KMT2A | |
| Bicarbonate SCHEMBL28904630 | 0.88 | TSHR (0.57) | TSHRKDM4EDUSP3MEN1KMT2A | |
| SCHEMBL16863053 | 0.88 | TSHR (0.61) | TSHRKDM4EDUSP3MEN1KMT2A | |
| SCHEMBL25707 | 0.88 | TSHR (0.61) | TSHRKDM4EDUSP3MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 118 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109401560-B | High-turnover-frequency ultraviolet-cured aluminum template release agent and preparation method thereof | 湖南汇田高分子科技有限公司 | 2021-10-08 | — | — | CN | claimed |
| EP-0973482-B2 | DENTAL PRIMER COMPOSITIONS | MINNESOTA MINING & MFG (US) | 2020-03-18 | — | — | EP | claimed |
| US-8664294-B2 | Self etch all purpose dental cement composition and method of use thereof | PENTRON CLINICAL TECHNOLOGIES, LLC (US) | 2014-03-04 | — | — | US | claimed |
| US-20110171608-A1 | SELF ETCH ALL PURPOSE DENTAL CEMENT COMPOSITION AND METHOD OF USE THEREOF | PENTRON CLINICAL TECHNOLOGIES, L.L.C. (US) | 2011-07-14 | — | — | US | claimed |
| EP-0973482-B1 | DENTAL PRIMER COMPOSITIONS | MINNESOTA MINING & MFG (US) | 2005-01-19 | — | — | EP | claimed |
| US-6482871-B1 | Method for adhering to hard tissue | 3M INNOVATIVE PROPERTIES COMPANY | 2002-11-19 | — | — | US | claimed |
| EP-0973482-A1 | DENTAL PRIMER COMPOSITIONS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 2000-01-26 | — | — | EP | claimed |
| US-5922786-A | PART A COMPRISES AN ACIDIC POLYMERIZABLE COMPOUND AND POLYMERIZABLE DILUENT SELECTED SO THAT IF WATER IS PRESENT, THE PH OF PART A IS GREATER THAN 2; PART B COMPRISES AN ACIDIC MATERIAL SUCH THAT THE PH IS 2; NO ETCHING STEP NEEDED | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1999-07-13 | — | — | US | claimed |
| WO-1998046198-A1 | DENTAL PRIMER COMPOSITIONS | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1998-10-22 | — | — | WO | claimed |
| CN-109401560-B | High-turnover-frequency ultraviolet-cured aluminum template release agent and preparation method thereof | 湖南汇田高分子科技有限公司 | 2021-10-08 | — | — | CN | disclosed |
| EP-0973482-B2 | DENTAL PRIMER COMPOSITIONS | MINNESOTA MINING & MFG (US) | 2020-03-18 | — | — | EP | disclosed |
| US-9901519-B2 | Infiltrant for dental ceramics | MUHLBAUER TECHNOLOGY GMBH (DE) | 2018-02-27 | — | — | US | disclosed |
| US-9833387-B2 | Kit and method for indirect chairside production of composite inlays | VOCO GMBH (DE) | 2017-12-05 | — | — | US | disclosed |
| US-9610235-B2 | Methods and compositions to improve mechanical resistance of teeth | THEOCORP HOLDING CO., LLC (US) | 2017-04-04 | — | — | US | disclosed |
| WO-1993012760-A1 | METHOD FOR ADHERING TO HARD TISSUE | MINNESOTA MINING AND MANUFACTURING COMPANY (US) | 1993-07-08 | — | — | WO | disclosed |
| US-4966934-A | DIPENTAERYTHRITOL PENTAACRYLATE PHOSPHATE ESTER; DENTISTRY | DENTSPLY RESEARCH & DEVELOPMENT CORP. (US) | 1990-10-30 | — | — | US | disclosed |
| EP-0363903-A2 | Adhesive containing pit and fissure sealants | DENTSPLY INTERNATIONAL (US) | 1990-04-18 | — | — | EP | disclosed |
| US-4816495-A | UNSATURATED PHOSPHATES AS ADHESION PROMOTERS | DENTSPLY RESEARCH & DEVELOPMENT CORP. (US) | 1989-03-28 | — | — | US | disclosed |
| US-4657941-A | USED IN DENTISTRY | DENTSPLY RESEARCH & DEVELOPMENT CORP. (US) | 1987-04-14 | — | — | US | disclosed |
| EP-0183027-A2 | Biologically compatible adhesive | DENTSPLY INTERNATIONAL, INC. (US) | 1986-06-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110171608-A1 | SELF ETCH ALL PURPOSE DENTAL CEMENT COMPOSITION AND METHOD OF USE THEREOF | FHIT, ASPH, ACR | TSHR 4798/4885KDM4E 1761/4885DUSP3 2450/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.