Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8904621 | 0.90 | NOTUM (0.49) | NOTUMMTNR1AMEN1KMT2AALDH1A1 | |
| SCHEMBL8905262 | 0.81 | MTNR1A (0.41) | NOTUMMTNR1AMEN1KMT2AALDH1A1 | |
| SCHEMBL8905128 | 0.79 | ALDH1A1 (0.45) | NOTUMALDH1A1GAAL3MBTL1NPSR1 | |
| SCHEMBL11756352 | 0.75 | MTNR1A (0.48) | NOTUMMTNR1AMEN1KMT2AALDH1A1 | |
| SCHEMBL8905306 | 0.74 | ALDH1A1 (0.52) | NOTUMMEN1KMT2AALDH1A1GAA | |
| SCHEMBL25268555 | 0.73 | NOTUM (0.45) | NOTUMALDH1A1L3MBTL1MAPTTSHR | |
| SCHEMBL26103110 | 0.73 | NOTUM (0.45) | NOTUMALDH1A1L3MBTL1MAPTTSHR | |
| SCHEMBL14229139 | 0.72 | MTNR1A (0.48) | MTNR1AL3MBTL1TSHRPKM | |
| SCHEMBL7831498 | 0.71 | POLB (0.56) | NOTUMMEN1KMT2AALDH1A1GAA | |
| SCHEMBL11622288 | 0.71 | NOTUM (0.47) | NOTUMMTNR1AMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616586-A | Tricyclic quinoxalinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0642508-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993008188-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-04-29 | — | — | WO | disclosed |