Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905266 | 0.83 | L3MBTL1 (0.32) | MAPTL3MBTL1GAA | |
| SCHEMBL8905130 | 0.81 | MAPT (0.34) | MAPTL3MBTL1GAA | |
| SCHEMBL9278165 | 0.73 | MAPT (0.38) | MAPTALDH1A1L3MBTL1GAA | |
| SCHEMBL8904624 | 0.70 | NOTUM (0.50) | MAPTALDH1A1L3MBTL1GAAKMT2A | |
| SCHEMBL8649597 | 0.67 | GAA (0.34) | MAPTL3MBTL1GAA | |
| SCHEMBL26970249 | 0.63 | ALDH1A1 (0.47) | USP2ALDH1A1ALOX15TDP1L3MBTL1 | |
| SCHEMBL16649052 | 0.60 | ALDH1A1 (0.52) | USP2ALDH1A1ALOX15TDP1L3MBTL1 | |
| SCHEMBL27740322 | 0.60 | ALDH1A1 (0.51) | USP2ALDH1A1ALOX15TDP1L3MBTL1 | |
| SCHEMBL18623243 | 0.59 | ALDH1A1 (0.50) | MAPTUSP2ALDH1A1ALOX15TDP1 | |
| SCHEMBL265785 | 0.59 | TDP1 (0.39) | USP2ALDH1A1ALOX15TDP1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616586-A | Tricyclic quinoxalinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0642508-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993008188-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-04-29 | — | — | WO | disclosed |