Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905311 | 0.88 | L3MBTL1 (0.33) | MAPTL3MBTL1GAA | |
| SCHEMBL8905266 | 0.82 | L3MBTL1 (0.32) | MAPTL3MBTL1GAA | |
| SCHEMBL8904625 | 0.81 | MAPT (0.34) | MAPTL3MBTL1GAA | |
| SCHEMBL9278165 | 0.76 | MAPT (0.38) | MAPTL3MBTL1GAALMNA | |
| SCHEMBL8905128 | 0.66 | ALDH1A1 (0.45) | MAPTL3MBTL1GAANPSR1LMNA | |
| SCHEMBL8649597 | 0.63 | GAA (0.34) | MAPTL3MBTL1GAA | |
| SCHEMBL11046596 | 0.62 | GSK3A (0.40) | MAPTNPSR1 | |
| SCHEMBL8905913 | 0.60 | KMT2A (0.33) | — | |
| SCHEMBL9736803 | 0.56 | — | — | |
| SCHEMBL1240961 | 0.56 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616586-A | Tricyclic quinoxalinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| EP-0642508-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1995-03-15 | — | — | EP | disclosed |
| WO-1993008188-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-04-29 | — | — | WO | disclosed |