SCHEMBL8905266

SCHEMBL8905266

CCOC(=O)C(=O)N1C2=CC=CCC2CCC1CO[Si](C)(C)C

nearest known ligand 0.32

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 1/20 0.32
MAPT P10636 1/20 0.32
GAA P10253 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8904625 0.83 MAPT (0.34) L3MBTL1MAPTGAA
SCHEMBL8905130 0.82 MAPT (0.34) L3MBTL1MAPTGAA
SCHEMBL9278165 0.72 MAPT (0.38) L3MBTL1MAPTGAA
SCHEMBL8905262 0.70 MTNR1A (0.41) L3MBTL1GAA
SCHEMBL8649597 0.65 GAA (0.34) L3MBTL1MAPTGAA
SCHEMBL8905913 0.58 KMT2A (0.33)
SCHEMBL8905128 0.56 ALDH1A1 (0.45) L3MBTL1MAPTGAA
SCHEMBL11789421 0.54 DRD2 (0.30)
SCHEMBL1240961 0.53
SCHEMBL3306197 0.53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5616586-A Tricyclic quinoxalinediones SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1997-04-01 US disclosed
WO-1993008188-A1 TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1993-04-29 WO disclosed