Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 10/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.37 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.37 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.37 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.37 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.37 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.37 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905262 | 0.86 | MTNR1A (0.41) | MTNR1AMEN1KMT2AACEL3MBTL1 | |
| SCHEMBL8905122 | 0.80 | MTNR1A (0.44) | MTNR1AMEN1KMT2AACEPOLB | |
| SCHEMBL8904621 | 0.77 | NOTUM (0.49) | MTNR1AMEN1KMT2A | |
| SCHEMBL7005115 | 0.74 | ACE (0.41) | MTNR1AMEN1KMT2AACEPDK1 | |
| SCHEMBL7007832 | 0.72 | MTNR1A (0.38) | MTNR1AMEN1KMT2AACE | |
| SCHEMBL8905304 | 0.72 | ALDH1A1 (0.51) | MTNR1AMEN1KMT2AACEPOLB | |
| SCHEMBL8355166 | 0.70 | PSEN1 (0.63) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8018491 | 0.69 | MTNR1A (0.51) | MTNR1AACEPOLBL3MBTL1PDK1 | |
| SCHEMBL11756352 | 0.69 | MTNR1A (0.48) | MTNR1AMEN1KMT2AACEPOLB | |
| SCHEMBL8905128 | 0.68 | ALDH1A1 (0.45) | ACEPOLBL3MBTL1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5616586-A | Tricyclic quinoxalinediones | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1997-04-01 | — | — | US | disclosed |
| WO-1993008188-A1 | TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1993-04-29 | — | — | WO | disclosed |