Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | RAF1 | P04049 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906007 | 0.89 | CXCL8 (0.37) | LMNAALDH1A1ALOX15NPSR1MAPT | |
| SCHEMBL8904932 | 0.82 | MAPT (0.40) | LMNAALDH1A1ALOX15NPSR1MAPT | |
| SCHEMBL8905554 | 0.81 | LMNA (0.45) | LMNAALDH1A1ALOX15NPSR1MAPT | |
| SCHEMBL9030442 | 0.76 | ABCB11 (0.42) | LMNAALDH1A1ALOX15NPSR1RAB9A | |
| SCHEMBL8905047 | 0.76 | AKR1B1 (0.37) | LMNAALDH1A1MAPTRAB9AKMT2A | |
| SCHEMBL11717034 | 0.76 | MAPT (0.49) | LMNAALDH1A1ALOX15NPSR1MAPT | |
| SCHEMBL11717374 | 0.74 | ALDH1A1 (0.46) | LMNAALDH1A1ALOX15NPSR1MAPT | |
| SCHEMBL7586143 | 0.74 | KMT2A (0.47) | LMNAALDH1A1ALOX15NPSR1MAPT | |
| SCHEMBL8905896 | 0.72 | PTGS2 (0.41) | LMNAALDH1A1NPSR1HTTHPGD | |
| SCHEMBL8904746 | 0.71 | NPSR1 (0.41) | LMNAALDH1A1ALOX15NPSR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622948-A | ANALGESICS | SYNTEX (U.S.A.) INC. (US) | 1997-04-22 | — | — | US | disclosed |
| EP-0714895-A1 | Pyrrole derivatives | F. Hoffmann-La Roche AG (CH) | 1996-06-05 | — | — | EP | disclosed |