Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 15/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.37 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 1/20 | 0.37 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906575 | 0.95 | AGTR2 (0.41) | PPARGAGTR1AGTR2 | |
| SCHEMBL8905753 | 0.94 | GPR119 (0.41) | PPARGGPR119 | |
| SCHEMBL8905700 | 0.82 | PPARG (0.50) | PPARGAGTR1KDM4EABCC3ABCC4 | |
| SCHEMBL8906316 | 0.81 | PPARG (0.44) | PPARGAGTR1KDM4EABCC3ABCC4 | |
| SCHEMBL8906593 | 0.81 | GPR119 (0.41) | PPARGGPR119PDE3ANPSR1 | |
| SCHEMBL8905974 | 0.80 | PPARG (0.45) | PPARGAGTR1KDM4EABCC3ABCC4 | |
| SCHEMBL8905609 | 0.80 | PPARG (0.41) | PPARGAGTR1KDM4EABCC3ABCC4 | |
| SCHEMBL8907335 | 0.80 | PPARG (0.39) | PPARGAGTR1KDM4EABCC3ABCC4 | |
| SCHEMBL8906342 | 0.79 | GPR119 (0.37) | PPARGGPR119HCAR1 | |
| SCHEMBL8905936 | 0.79 | GPR119 (0.35) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |