SCHEMBL8906342

SCHEMBL8906342

CCCc1nc2ccc(-c3ccc(=O)[nH]n3)cc2n1-c1cc(-c2nnn[nH]2)cc(-c2ccccc2)c1C

nearest known ligand 0.37

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 1/20 0.37
HCAR1 Q9BXC0 1/20 0.36
PPARG P37231 8/20 0.35
CYP1A2 P05177 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8905936 0.84 GPR119 (0.35) GPR119
SCHEMBL8906411 0.83 GPR119 (0.38) GPR119CYP1A2
SCHEMBL8905970 0.79 PPARG (0.41) GPR119HCAR1PPARG
SCHEMBL8789878 0.77 PPARG (0.51) PPARG
SCHEMBL8906575 0.75 AGTR2 (0.41) PPARG
SCHEMBL8905753 0.73 GPR119 (0.41) GPR119PPARGCYP1A2
SCHEMBL8789873 0.73 AGTR1 (0.53)
SCHEMBL8905804 0.72 KDM4E (0.40) PPARG
SCHEMBL8905808 0.72 ALDH1A1 (0.39) PPARG
SCHEMBL8790413 0.72 AGTR1 (0.46) PPARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5684029-A HYPOTENSIVE AGENTS KARL THOMAE GMBH (DE) 1997-11-04 US disclosed