Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.60 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.60 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.60 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.56 |
| ▸ | CDK9 | P50750 | 1/20 | 0.56 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.56 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | CNR1 | P21554 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.53 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL714237 | 0.87 | SMN1; SMN2 (0.73) | ALDH1A1TAAR1SMN1; SMN2TP53EPHX1 | |
| SCHEMBL5359926 | 0.85 | SMN1; SMN2 (0.77) | PTPN1PTPN11TAAR1SMN1; SMN2TP53 | |
| SCHEMBL10155599 | 0.85 | ALDH1A1 (0.78) | ALDH1A1TAAR1SMN1; SMN2TP53EPHX1 | |
| SCHEMBL9479624 | 0.84 | CASP3 (0.77) | ALDH1A1TAAR1SMN1; SMN2TP53EPHX1 | |
| SCHEMBL13680444 | 0.83 | CNR1 (0.62) | ALDH1A1SMN1; SMN2KMT2ACNR1MGLL | |
| SCHEMBL12444550 | 0.82 | KIF11 (0.61) | ALDH1A1SMN1; SMN2TP53NPC1RAB9A | |
| SCHEMBL23072523 | 0.81 | ALDH1A1 (0.68) | ALDH1A1TAAR1SMN1; SMN2TP53EPHX1 | |
| SCHEMBL21504845 | 0.81 | CA1 (0.57) | ALDH1A1PTPN1TAAR1SMN1; SMN2TP53 | |
| SCHEMBL11177479 | 0.81 | MDM2 (0.59) | ALDH1A1TAAR1RAB9AKMT2ACNR1 | |
| SCHEMBL16866541 | 0.79 | ALDH1A1 (0.55) | ALDH1A1TAAR1SMN1; SMN2TP53EPHX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9611271-B2 | C20′ urea derivatives of vinca alkaloids | SCRIPPS RESEARCH INSTITUTE (US) | 2017-04-04 | — | — | US | disclosed |
| US-20150291610-A1 | C20' Urea Derivatives of Vinca Alkaloids | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-10-15 | — | — | US | disclosed |
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150291610-A1 | C20' Urea Derivatives of Vinca Alkaloids | UTP18, SNRPA1, SNRPA | ALDH1A1 774/4885PTPN1 4597/4885PTPN11 4647/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.