Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | THRB | P10828 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.41 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8157670 | 0.82 | TDP1 (0.45) | TDP1TSHRCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL11695120 | 0.81 | TDP1 (0.41) | TDP1TSHRCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL7274967 | 0.77 | SIGMAR1 (0.50) | AOC3 | |
| SCHEMBL15007253 | 0.73 | ALDH1A1 (0.50) | CYP3A4ALDH1A1HSD17B10LMNASMN1; SMN2 | |
| SCHEMBL2495982 | 0.73 | TDP1 (0.54) | TDP1TSHRCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL4457363 | 0.73 | TDP1 (0.61) | TDP1TSHRCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL7708792 | 0.72 | TDP1 (0.48) | TDP1TSHRCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL28307330 | 0.72 | SIGMAR1 (0.48) | TDP1TSHRCYP3A4ALDH1A1THRB | |
| SCHEMBL24134692 | 0.71 | ACHE (0.37) | TDP1TSHRALDH1A1HSD17B10LMNA | |
| Methane SCHEMBL28523284 | 0.71 | TDP1 (0.52) | TDP1TSHRCYP3A4ALDH1A1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5672605-A | ADMINISTERING TO TREAT AUTOIMMUNE DISORDERS, TRANSPLANT REJECTION | ABBOTT LABORATORIES (US) | 1997-09-30 | — | — | US | disclosed |
| US-5583139-A | Marcolide immunomodulators | ABBOTT LABORATORIES (US) | 1996-12-10 | — | — | US | disclosed |
| US-5527907-A | IMMUNOSUPPRESSANTS | ABBOTT LABORATORIES (US) | 1996-06-18 | — | — | US | disclosed |