Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S100A4 | P26447 | 1/20 | 0.32 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | APAF1 | O14727 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908304 | 0.81 | SMN1; SMN2 (0.33) | TNKS2KDM4EAPAF1POLBRAB9A | |
| SCHEMBL9815972 | 0.67 | PTPRC (0.42) | S100A4APAF1POLBRAB9APAX8 | |
| SCHEMBL8907884 | 0.67 | S100A4 (0.36) | S100A4TNKS2KDM4EAPAF1POLB | |
| SCHEMBL6237073 | 0.65 | POLB (0.58) | APAF1POLBRAB9APAX8 | |
| SCHEMBL8908559 | 0.65 | ALDH1A1 (0.53) | APAF1POLBRAB9APAX8 | |
| SCHEMBL6904734 | 0.63 | MEN1 (0.52) | S100A4KDM4EAPAF1POLBRAB9A | |
| SCHEMBL8908233 | 0.62 | KMT2A (0.41) | POLBPAX8 | |
| SCHEMBL8908230 | 0.62 | KMT2A (0.41) | POLBPAX8 | |
| Ethylene SCHEMBL8908925 | 0.62 | ALDH1A1 (0.50) | APAF1POLBRAB9APAX8 | |
| SCHEMBL5343918 | 0.62 | GPR3 (0.46) | S100A4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | claimed |
| US-5646146-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1997-07-08 | — | — | US | claimed |
| EP-0682657-A1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-11-22 | — | — | EP | claimed |
| WO-1994018175-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-08-18 | — | — | WO | claimed |
| EP-0682657-B1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK AS (DK) | 1997-11-19 | — | — | EP | disclosed |
| US-5646146-A | CENTRAL NERVOUS SYSTEM DISORDERS | NOVO NORDISK A/S (DK) | 1997-07-08 | — | — | US | disclosed |
| EP-0682657-A1 | 9H-INDENO[1,2-b]PYRAZINE-3(4H)-ONES AND 9H-INDENO[1,2-b]PYRAZINE-2,3(1H,4H)-DIONES AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1995-11-22 | — | — | EP | disclosed |
| US-5468748-A | Nervous system and psychological disorders; antagonize glycine binding site on N-methylaspartic acid receptor complex | NOVO NORDISK A/S (DK) | 1995-11-21 | — | — | US | disclosed |
| WO-1994018175-A1 | HETEROCYCLIC COMPOUNDS AND THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1994-08-18 | — | — | WO | disclosed |