Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 5/20 | 0.46 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.44 |
| ▸ | PDE4A | P27815 | 2/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.43 |
| ▸ | PDE10A | Q9Y233 | 2/20 | 0.43 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8669643 | 0.74 | CYSLTR1 (0.72) | ALOX5CYSLTR1CYSLTR2FFAR1AKR1B1 | |
| SCHEMBL2566640 | 0.73 | CYSLTR2 (0.56) | ALOX5CYSLTR1CYSLTR2PDE4APDE4B | |
| SCHEMBL7604022 | 0.73 | ALOX5 (0.57) | ALOX5CYSLTR1CYSLTR2ALOX5APPDE4A | |
| SCHEMBL8557912 | 0.73 | ALOX5 (0.55) | ALOX5CYSLTR1CYSLTR2 | |
| SCHEMBL2564677 | 0.73 | PDE10A (0.54) | ALOX5CYSLTR1CYSLTR2PDE4APDE4B | |
| SCHEMBL8557925 | 0.73 | ALOX5 (0.56) | ALOX5CYSLTR1CYSLTR2ALOX5APPDE4A | |
| SCHEMBL8557903 | 0.73 | ALOX5 (0.56) | ALOX5CYSLTR1CYSLTR2ALOX5APPDE4A | |
| SCHEMBL2566437 | 0.70 | CYSLTR2 (0.53) | ALOX5CYSLTR1CYSLTR2ALOX5APPDE4A | |
| SCHEMBL8557907 | 0.69 | ALOX5 (0.49) | ALOX5CYSLTR1CYSLTR2ALOX5APPDE4A | |
| SCHEMBL9387167 | 0.69 | CYSLTR1 (0.56) | CYSLTR1CYSLTR2PDE10AGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997012866-A1 | BIS-HETEROARYLYLMETHOXYPHENYLKETONE DERIVATIVES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | ABBOTT LABORATORIES (US) | 1997-04-10 | — | — | WO | disclosed |