Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.41 |
| ▸ | PTGS1 | P23219 | 6/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8991936 | 0.71 | PTGS2 (0.41) | PTGS2PTGS1SMN1; SMN2NPSR1ALOX5 | |
| SCHEMBL8580642 | 0.71 | PTGS2 (0.57) | PTGS2PTGS1CYP1A2CYP2C9KMT2A | |
| SCHEMBL8991938 | 0.71 | PTGS2 (0.41) | PTGS2PTGS1SMN1; SMN2NPSR1ALOX5 | |
| SCHEMBL8978921 | 0.70 | PTGS1 (0.48) | PTGS2PTGS1SMN1; SMN2NPSR1ALOX5 | |
| SCHEMBL8978903 | 0.70 | PTGS2 (0.55) | PTGS2PTGS1SMN1; SMN2NPSR1ALOX5 | |
| SCHEMBL8978913 | 0.70 | PTGS2 (0.55) | PTGS2PTGS1SMN1; SMN2NPSR1ALOX5 | |
| SCHEMBL8580718 | 0.69 | MAPT (0.42) | PTGS2PTGS1SMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL8910093 | 0.68 | LMNA (0.37) | PTGS2PTGS1SMN1; SMN2NPSR1KMT2A | |
| SCHEMBL8962158 | 0.68 | PTGS2 (0.56) | PTGS2PTGS1SMN1; SMN2NPSR1CYP1A2 | |
| SCHEMBL8895686 | 0.68 | MEN1 (0.40) | PTGS2PTGS1SMN1; SMN2NPSR1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5691367-A | ANTIINFLAMMATORY AGENTS OR ANTIARTHRITIC AGENTS | ELI LILLY AND COMPANY (US) | 1997-11-25 | — | — | US | disclosed |