Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 9/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908776 | 0.79 | SIGMAR1 (0.41) | SIGMAR1EPHX2EPHX1ALDH1A1 | |
| SCHEMBL8909879 | 0.69 | SIGMAR1 (0.43) | SIGMAR1HSD11B1CNR2 | |
| SCHEMBL8908667 | 0.69 | SIGMAR1 (0.40) | SIGMAR1HSD11B1ALDH1A1 | |
| SCHEMBL8910607 | 0.69 | BPTF (0.49) | SIGMAR1EPHX1HSD11B1ALDH1A1TSHR | |
| SCHEMBL8910246 | 0.67 | SIGMAR1 (0.43) | SIGMAR1EPHX1HSD11B1TSHR | |
| SCHEMBL8909808 | 0.66 | SIGMAR1 (0.53) | SIGMAR1HSD11B1 | |
| SCHEMBL3813465 | 0.65 | HDAC1 (0.46) | EPHX2ALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL4608058 | 0.65 | HDAC2 (0.36) | SIGMAR1EPHX2ALDH1A1TSHR | |
| SCHEMBL3812022 | 0.64 | HDAC1 (0.46) | ATMALDH1A1MEN1KMT2ATSHR | |
| SCHEMBL8910605 | 0.63 | SIGMAR1 (0.60) | SIGMAR1HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658923-A | USED IN TREATING DISEASES RELATED TO SIGMA-RECEPTOR, SUCH AS SCHIZOPHRENIA | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1997-08-19 | — | — | US | disclosed |