SCHEMBL8908847

SCHEMBL8908847

Fc1cccc(/C=N/Nc2nc(NCc3ccc(Cl)nc3)nc(Nc3ccc(F)c(C(F)(F)F)c3)n2)c1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC2A1 P11166 1/20 0.43
MAPT P10636 4/20 0.42
MAPK1 P28482 2/20 0.42
STK17A Q9UEE5 2/20 0.42
STK17B O94768 1/20 0.42
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
LMNA P02545 2/20 0.41
HTT P42858 2/20 0.41
ALDH1A1 P00352 1/20 0.41
TDP1 Q9NUW8 1/20 0.41
NPC1 O15118 2/20 0.40
RAB9A P51151 2/20 0.40
NTRK1 P04629 5/20 0.39
PKM P14618 1/20 0.38
PTK2 Q05397 2/20 0.38
DDX3X O00571 2/20 0.38
KCNH3 Q9ULD8 1/20 0.37
NPSR1 Q6W5P4 2/20 0.37
KCNQ3 O43525 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8908807 0.94 SLC2A1 (0.44) SLC2A1MAPTMAPK1STK17ASTK17B
SCHEMBL8909751 0.93 SLC2A1 (0.43) SLC2A1MAPTMAPK1STK17ASTK17B
SCHEMBL13883263 0.92 SLC2A1 (0.42) SLC2A1MAPTMAPK1STK17ASTK17B
SCHEMBL8910086 0.92 MAPT (0.46) SLC2A1MAPTMAPK1STK17ASTK17B
SCHEMBL8908824 0.91 KCNH3 (0.43) SLC2A1MAPTSTK17ASTK17BMEN1
SCHEMBL8909727 0.90 STK17A (0.42) SLC2A1MAPTSTK17ASTK17BMEN1
SCHEMBL8909756 0.90 SLC2A1 (0.46) SLC2A1MAPTMAPK1STK17ASTK17B
SCHEMBL8908953 0.90 KCNH3 (0.44) SLC2A1MAPTSTK17ASTK17BMEN1
SCHEMBL8908985 0.90 SLC2A1 (0.41) SLC2A1MAPTMAPK1STK17ASTK17B
SCHEMBL8909772 0.89 STK17A (0.42) SLC2A1MAPTSTK17ASTK17BMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 US disclosed
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ SLC2A1 4129/4885MAPT 2948/4885MAPK1 3363/4885
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ SLC2A1 4129/4885MAPT 2948/4885MAPK1 3363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.