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SCHEMBL8909727

SCHEMBL8909727

Fc1ccc(Nc2nc(NCc3ccc(Cl)nc3)nc(N/N=C/c3cc(Cl)cc(Cl)c3)n2)cc1C(F)(F)F

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ STK17A Q9UEE5 2/20 0.42
▸ SLC2A1 P11166 1/20 0.42
▸ STK17B O94768 1/20 0.42
▸ KCNQ3 O43525 1/20 0.38
▸ KCNQ2 O43526 1/20 0.38
▸ KCNE1 P15382 1/20 0.38
▸ KCNQ1 P51787 1/20 0.38
▸ DDX3X O00571 2/20 0.38
▸ KCNH3 Q9ULD8 3/20 0.38
▸ VNN1 O95497 5/20 0.37
▸ PTK2 Q05397 2/20 0.36
▸ CA12 O43570 2/20 0.34
▸ CA1 P00915 2/20 0.34
▸ CA2 P00918 2/20 0.34
▸ CA9 Q16790 2/20 0.34
▸ KDM4E B2RXH2 2/20 0.34
▸ ALDH1A1 P00352 2/20 0.34
▸ SMN1; SMN2 Q16637 2/20 0.34
▸ GAA P10253 1/20 0.34
▸ MEN1 O00255 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8909756 0.93 SLC2A1 (0.46) STK17ASLC2A1STK17BKCNQ3KCNQ2
SCHEMBL8908807 0.93 SLC2A1 (0.44) STK17ASLC2A1STK17BKCNQ3KCNQ2
SCHEMBL8908824 0.92 KCNH3 (0.43) STK17ASLC2A1STK17BKCNQ3KCNQ2
SCHEMBL8909667 0.92 CA12 (0.44) STK17ASLC2A1STK17BKCNQ3KCNQ2
SCHEMBL8909772 0.91 STK17A (0.42) STK17ASLC2A1STK17BKCNQ3KCNQ2
SCHEMBL8908847 0.90 SLC2A1 (0.43) STK17ASLC2A1STK17BKCNQ3KCNQ2
SCHEMBL8909751 0.89 SLC2A1 (0.43) STK17ASLC2A1STK17BDDX3XPTK2
SCHEMBL606991 0.89 MEN1 (0.40) STK17ASLC2A1STK17BKCNQ3KCNQ2
SCHEMBL606990 0.89 MEN1 (0.40) STK17ASLC2A1STK17BKCNQ3KCNQ2
SCHEMBL8910086 0.89 MAPT (0.46) STK17ASLC2A1STK17BKCNQ3KCNQ2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 — — US disclosed
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 — — US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 — — US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 — — US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 — — US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 — — US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 — — US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ STK17A 2330/4885SLC2A1 4129/4885STK17B 2423/4885
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ STK17A 2330/4885SLC2A1 4129/4885STK17B 2423/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.