Sugi Predict

Sugi Predict / Compounds / SCHEMBL8910086

SCHEMBL8910086

SCHEMBL8910086

Fc1ccc(Nc2nc(NCc3ccc(Cl)nc3)nc(N/N=C/c3cccc(Br)c3)n2)cc1C(F)(F)F

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MAPT P10636 5/20 0.46
▸ NPSR1 Q6W5P4 3/20 0.46
▸ MAPK1 P28482 3/20 0.46
▸ SLC2A1 P11166 1/20 0.42
▸ STK17A Q9UEE5 3/20 0.39
▸ STK17B O94768 2/20 0.39
▸ PTK2 Q05397 3/20 0.38
▸ KDM4E B2RXH2 2/20 0.37
▸ GAA P10253 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ DDX3X O00571 2/20 0.37
▸ LMNA P02545 2/20 0.36
▸ HTT P42858 1/20 0.36
▸ POLB P06746 1/20 0.35
▸ KMT2A Q03164 1/20 0.35
▸ KCNQ3 O43525 1/20 0.35
▸ KCNQ2 O43526 1/20 0.35
▸ KCNE1 P15382 1/20 0.35
▸ KCNQ1 P51787 1/20 0.35
▸ KCNH3 Q9ULD8 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8908807 0.93 SLC2A1 (0.44) MAPTNPSR1MAPK1SLC2A1STK17A
SCHEMBL8908847 0.92 SLC2A1 (0.43) MAPTNPSR1MAPK1SLC2A1STK17A
SCHEMBL8909751 0.91 SLC2A1 (0.43) MAPTNPSR1MAPK1SLC2A1STK17A
SCHEMBL13883263 0.91 SLC2A1 (0.42) MAPTNPSR1MAPK1SLC2A1STK17A
SCHEMBL8909756 0.89 SLC2A1 (0.46) MAPTMAPK1SLC2A1STK17ASTK17B
SCHEMBL8909727 0.89 STK17A (0.42) MAPTSLC2A1STK17ASTK17BPTK2
SCHEMBL8908953 0.89 KCNH3 (0.44) MAPTNPSR1SLC2A1STK17ASTK17B
SCHEMBL8908985 0.89 SLC2A1 (0.41) MAPTNPSR1MAPK1SLC2A1STK17A
SCHEMBL8909772 0.88 STK17A (0.42) MAPTSLC2A1STK17ASTK17BPTK2
SCHEMBL8908824 0.88 KCNH3 (0.43) MAPTNPSR1SLC2A1STK17ASTK17B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 — — US disclosed
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 — — US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 — — US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 — — US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 — — US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 — — US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 — — US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ MAPT 2948/4885NPSR1 3869/4885MAPK1 3363/4885
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ MAPT 2948/4885NPSR1 3869/4885MAPK1 3363/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.