SCHEMBL8908857

SCHEMBL8908857

Oc1ccc(C2(c3ccc(O)cc3)CCC(O)CC2)cc1

nearest known ligand 0.61

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
ESR2 Q92731 10/20 0.61
ESR1 P03372 4/20 0.61
SLC6A4 P31645 4/20 0.38
SLC6A3 Q01959 4/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL157149 0.92 ESR2 (0.53) ESR2ESR1SLC6A4SLC6A3
SCHEMBL8148479 0.88 ESR2 (0.53) ESR2ESR1SLC6A4SLC6A3
SCHEMBL45825 0.84 ESR2 (0.64) ESR2ESR1
SCHEMBL7530533 0.81 ESR2 (0.80) ESR2ESR1SLC6A4SLC6A3
SCHEMBL3811364 0.81 ESR2 (0.80) ESR2ESR1SLC6A4SLC6A3
SCHEMBL237553 0.81 ESR2 (0.59) ESR2ESR1
SCHEMBL1046438 0.80 OPRM1 (0.50) SLC6A4SLC6A3
SCHEMBL2951103 0.79 ESR2 (0.61) ESR2ESR1
SCHEMBL17636594 0.79 ESR2 (0.57) ESR2ESR1
SCHEMBL17636592 0.79 ESR2 (0.57) ESR2ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0287290-B1 PREPARATION PROCESS OF 4,4'-BIPHENOL, PRECURSOR OF SAME AND PREPARATION PROCESS OF PRECURSOR MITSUI TOATSU CHEMICALS, Inc. (JP) 1992-07-08 EP claimed
EP-0251614-B1 PROCESS FOR THE PREPARATION OF 4,4'-BIPHENOL MITSUI TOATSU CHEMICALS, Inc. (JP) 1991-05-15 EP claimed
US-4939306-A Dehydrogevation by catalysis of 4-(4-hydroxyphenyl)-3-cyclohexene-1-ol by-product inhibition MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1990-07-03 US claimed
US-4877907-A DEHYDROGENATION OF 4-(4-HYDROXYPHENYL)-3-CYCLOHEXENE-1-OL MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1989-10-31 US claimed
EP-0287290-A1 Preparation process of 4,4'-biphenol, precursor of same and preparation process of precursor MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-10-19 EP claimed
US-4723046-A CATALYTIC DEHYDROGENATION OF 4,4-BIS(4-HYDROXYPHENYL) CYCLOHEXANOL MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1988-02-02 US claimed
EP-0251614-A1 Process for the preparation of 4,4'-biphenol MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-01-07 EP claimed
JP-1160930-A None JP disclosed
JP-63002938-A None JP disclosed
US-5691351-A Bis-(Heteroarylmethoxyphenyl)cycloalkyl carboxylates as inhibitors of leukotriene biosynthesis ABBOTT LABORATORIES (US) 1997-11-25 US disclosed
WO-1997029090-A1 BIS-(HETEROARYLMETHOXYPHENYL)CYCLOALKYL DERIVATIVES, THEIR PREPARATION AND THEIR USE AS INHIBITORS OF LEUKOTRIENE BIOSYTHESIS ABBOTT LABORATORIES (US) 1997-08-14 WO disclosed
EP-0287290-B1 PREPARATION PROCESS OF 4,4'-BIPHENOL, PRECURSOR OF SAME AND PREPARATION PROCESS OF PRECURSOR MITSUI TOATSU CHEMICALS, Inc. (JP) 1992-07-08 EP disclosed
EP-0303398-B1 PREPARATION PROCESS OF 4-(4-HYDROXYPHENYL)-CYCLOHEXANOL MITSUI TOATSU CHEMICALS, Inc. (JP) 1991-12-11 EP disclosed
EP-0287290-A1 Preparation process of 4,4'-biphenol, precursor of same and preparation process of precursor MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-10-19 EP disclosed
EP-0287290-A1 Preparation process of 4,4'-biphenol, precursor of same and preparation process of precursor MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-10-19 EP disclosed
US-4723046-A CATALYTIC DEHYDROGENATION OF 4,4-BIS(4-HYDROXYPHENYL) CYCLOHEXANOL MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1988-02-02 US disclosed
US-4723046-A CATALYTIC DEHYDROGENATION OF 4,4-BIS(4-HYDROXYPHENYL) CYCLOHEXANOL MITSUI TOATSU CHEMICALS, INCORPORATED (JP) 1988-02-02 US disclosed
EP-0251614-A1 Process for the preparation of 4,4'-biphenol MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-01-07 EP disclosed
EP-0251614-A1 Process for the preparation of 4,4'-biphenol MITSUI TOATSU CHEMICALS, Inc. (JP) 1988-01-07 EP disclosed
JP-S632938-A PRODUCTION OF 4,4'-BIPHENOL MITSUI TOATSU CHEM INC 1988-01-07 JP disclosed