Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABBR2 | O75899 | 1/20 | 0.56 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.56 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP7 | P09237 | 1/20 | 0.42 |
| ▸ | MMP14 | P50281 | 1/20 | 0.42 |
| ▸ | EEF2K | O00418 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7073753 | 0.91 | GABBR2 (0.50) | GABBR2GABBR1HSD11B1MAPTKDM4E | |
| SCHEMBL27603418 | 0.90 | HSD11B1 (0.51) | GABBR2GABBR1HSD11B1MAPTCYP2C19 | |
| SCHEMBL7077840 | 0.89 | GABBR2 (0.49) | GABBR2GABBR1HSD11B1MAPTMMP2 | |
| SCHEMBL7077860 | 0.89 | GABBR2 (0.49) | GABBR2GABBR1HSD11B1MAPTMMP2 | |
| SCHEMBL7080823 | 0.85 | GABBR2 (0.49) | GABBR2GABBR1HSD11B1MAPTCYP2C19 | |
| SCHEMBL5278801 | 0.84 | BDKRB1 (0.47) | GABBR2GABBR1MAPTKDM4ECYP2C19 | |
| SCHEMBL7133113 | 0.83 | MEN1 (0.47) | GABBR2GABBR1HSD11B1MAPTMEN1 | |
| SCHEMBL27852421 | 0.80 | HSD11B1 (0.47) | HSD11B1MAPTCYP2C19MEN1KMT2A | |
| SCHEMBL503819 | 0.79 | GABBR2 (0.76) | GABBR2GABBR1MAPTKDM4ECYP2C19 | |
| SCHEMBL5074951 | 0.79 | CYP1A2 (0.51) | HSD11B1MAPTCYP2C19MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |